Anti-Notch1/MOTC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Leverancier: Bioss
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BS-1335R-A750
BOSSBS-1335R-A750EA 874 EUR
BOSSBS-1335R-A750
Anti-Notch1/MOTC Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Antilichamen
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important forMore Product Information
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