U heeft gezocht op: Eiwitten en peptiden

Leverancier: SELENOZYME

Omschrijving: The human DIO2 selenocprotein is encoded by the DIO2 gene and catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination.
We provide the human DIO2 enzyme with approx. 20% Sec contents, mixed with inactive forms containing Sec-to-Lys and Sec-to-Gln substitutions, at more than 95% purity in aliquots at amounts from 50 to 500 µg.

Leverancier: SELENOZYME

Omschrijving: The TGR selenoprotein of Schistosoma mansoni is the only major reductive cytosolic flavoprotein of this parasite, taking over the combined role of TrxR1 and glutathione reductase, thereby exerting a wide range of functions in redox control and antioxidant systems and being a promising drug target for treatment of schistosomiasis.
We provide the main the Schistosoma mansoni TGR enzyme with more than 90% Sec contents and more than 95% purity in aliquots at amounts from 5 to 50 units.

Catalogus nummer: (NOVUNBP2-58159PEP)

Leverancier: Novus Biologicals

Omschrijving: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human COL11A1.

UOM: 1 * 1 EA

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Catalogus nummer: (ENZOBMLP2310001)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: AMPK substrate

UOM: 1 * 1 mg

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Catalogus nummer: (ENZOBMLP2050500)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: PKC inhibitor

UOM: 1 * 0,5 mg

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Catalogus nummer: (ENZOBMLP2240005)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: Elastase substrate

UOM: 1 * 5 mg

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Catalogus nummer: (SHBTPB-500-10)

Leverancier: Shenandoah Biotechnology

Omschrijving: Cytokines for polarizing T cells into T regulatory cells. T regulatory cells (Tregs) are a subset of T cells that suppress immune function. They are characterized by the expression of CD4, CD25 and Foxp3 and are known to produce immunosuppressive cytokines TGF-β 1 and IL-10. Tregs can be cultured from naive CD4+ T cells by culturing them in the presence of IL-2 and TGF-β 1 with CD3 and CD28 stimulation. In some cases cells are also cultured with neutralizing antibodies to IL-4, IFNγ and IL-12 and/or retinoic acid.

UOM: 1 * 1 Kit

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Catalogus nummer: (SHBTPB-500-03)

Leverancier: Shenandoah Biotechnology

Omschrijving: Cytokines for expansion and cell culture of human hematopoietic stem cells. Hematopoietic stem cells are self renewing pluripotent cells often characterised by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of TPO, SCF, and FLT-3 Ligand for short time periods allows CD34+ cells to proliferate without decreasing CD34 expression, thus retaining their stem cell properties. The combination of these cytokines allows for the <i>ex vivo</i> expansion of the most immature hematopoietic stem cells in cord blood or bone marrow preparations, but can be supplemented with other cytokines to promote specific lineages. For example, GM-CSF and/or G-CSF can be added to promote monocytes and granulocytes while EPO can be added to promote erthroid cells.

UOM: 1 * 1 Kit

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Catalogus nummer: (ENZOBMLG4200001)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: Phospholipase activator

UOM: 1 * 1 mg

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Catalogus nummer: (ENZOBMLG4450001)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: Ultra-pure

UOM: 1 * 1 mg

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Leverancier: Shenandoah Biotechnology

Omschrijving: IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.

New Product

Leverancier: ENZO LIFE SCIENCES

Omschrijving: MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20 nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0,85 and 0,1 μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

New Product

Leverancier: Shenandoah Biotechnology

Omschrijving: Neutrophil activating peptide 2 (NAP-2), also known as CXCL7, is a member of the CXC family of chemokines. NAP-2 is a carboxyl-terminal fragment produced by proteolytic cleavage of the platelet basic protein (PBP). NAP-2 is released from platelets and binds to the receptors CXCR1 and CXCR2 to chemoattract and activate neutrophils during inflammatory events.

New Product

Leverancier: Shenandoah Biotechnology

Omschrijving: B cell-attracting chemokine 1 (BCA-1), also known as CXCL13, is expressed at high levels in lymphoid tissues, such as the spleen, lymph nodes, and Peyer's patches.  BCA-1 activates signaling through the receptor Burkitt lymphoma receptor 1 (BLR1) to chemoattract B cells.

New Product

Catalogus nummer: (ENZOBMLAW94850100)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: Highly specific aldehyde based inhibitor of the caspase-like peptidic activity of the 20S proteasome.

UOM: 1 * 1 EA

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Catalogus nummer: (PRSI92-248)

Leverancier: ProSci Inc.

Omschrijving: Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

UOM: 1 * 0,05 mg

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