Anti-CD4 Rat Monoclonal Antibody [clone: GK1.5]

Leverancier: Tonbo Biosciences
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40-0041-U500 40-0041-M001 40-0041-U100
40-0041-U500EA 147 EUR
40-0041-U500 40-0041-M001 40-0041-U100
Anti-CD4 Rat Monoclonal Antibody [clone: GK1.5]
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The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells

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