Anti-KRT8/KRT18 Mouse Monoclonal Antibody [clone: B22.1 & B23.1]

Leverancier: IMMUNOLOGIC
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ILM8493-C01 ILM8493-C05 ILM8493-C1
ILM8493-C01EA 103 EUR
ILM8493-C01 ILM8493-C05 ILM8493-C1
Anti-KRT8/KRT18 Mouse Monoclonal Antibody [clone: B22.1 & B23.1]
Antilichamen
Cytokeratins 8 & 18 (CK 8 & 18) can be found in most simple epithelia, e.g. thyroid, breast, gastrointestinal tract, and respiratory tract. Adenocarcinomas and most non-keratinizing squamous carcinomas will stain with anti-CK 8 & 18, but keratinizing squamous carcinomas will not.1,2 This antibody is used when attempting to demonstrate the presence of Paget cells; there is very little keratin 18 in the normal epidermis so this will only stain Paget cells.3 The use of immunostaining facilitates interpretation and has been shown to be more sensitive than genetic analysis in colorectal carcinoma metastases.4

  • Visualization: cytoplasmic
  • Control: prostate, pancreas
  • Dilution Range: 1:100-1:500

References
1. Angus B, et al. J Pathol. 1987; 155:377-84.
2. Corson, JM. Pathol Annu. 1986; 21:47-81.
3. Liegl B, et al. Histopathology. 2007; 50:439-47.
4. Sasaki M, et al. Histopathology. 1998; 32:199-208.

Type: Primary
Antigen: KRT8/KRT18
Clonality: Monoclonal
Clone: B22.1 & B23.1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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