Anti-IGHM Mouse Monoclonal Antibody (CF568) [clone: ICO-30]

Leverancier: Biotium
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BNC680364-500 BNC680364-100
BNC680364-500EA 560 EUR
BNC680364-500 BNC680364-100
Anti-IGHM Mouse Monoclonal Antibody (CF568) [clone: ICO-30]
Antilichamen
Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Type: Primary
Antigen: IGHM
Clonality: Monoclonal
Clone: ICO-30
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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