Anti-ITGB4 Mouse Monoclonal Antibody (CF647) [clone: UM-A9]

Leverancier: Biotium
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BNC470449-500 BNC470449-100
BNC470449-500EA 560 EUR
BNC470449-500 BNC470449-100
Anti-ITGB4 Mouse Monoclonal Antibody (CF647) [clone: UM-A9]
Antilichamen
Recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Type: Primary
Antigen: ITGB4
Clonality: Monoclonal
Clone: UM-A9
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human
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