Anti-CCND1 Mouse Monoclonal Antibody (CF488A) [clone: CCND1/809]

Leverancier: Biotium
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BNC880809-500 BNC880809-100
BNC880809-500EA 560 EUR
BNC880809-500 BNC880809-100
Anti-CCND1 Mouse Monoclonal Antibody (CF488A) [clone: CCND1/809]
Antilichamen
Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express CyclinMore Product Information
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Specificaties

antigeen symbool CCND1
Type antilichaam Primair,Cyclin D1
Environmentally Preferable
Type antilichaam Primair,Cyclin D1
Clonality Monoklonaal
Conjugatie CF® 488A
Clone Clone CCND1/809
Reactivity Human
Host Mouse
Gen-ID 523852 , 667996
Isotype IgG2a kappa
Western blot Yes
ImmunoChemie Yes
ImmunoFluorescentie Yes
Concentratie 0,1 mg/ml
Opslagbuffer PBS/0,1% BSA/0,05% azide

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