Anti-CYCS Mouse Monoclonal Antibody (Purified) [clone: CTC05]

Leverancier: Biotium
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BNUB0887-500 BNUB0887-100
BNUB0887-500EA 511 EUR
BNUB0887-500 BNUB0887-100
Anti-CYCS Mouse Monoclonal Antibody (Purified) [clone: CTC05]
Antilichamen
Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.

Type: Primary
Antigen: CYCS
Clonality: Monoclonal
Clone: CTC05
Conjugation: Purified
Epitope:
Host: Mouse
Reactivity: Dog, Drosophila, Frog, Horse, Human, Mouse, Pigeon, Rat
Isotype: IgG2b, kappa
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