Furin convertase inhibitor (chloromethylketone)
Leverancier: ENZO LIFE SCIENCESTotal Ratings: 0
Avg. Ratings: 0.0 out of 5
Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1 nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki= 2,0nM), SPC4/PACE4 (Ki=3,6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0,12 nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25 to100 µm.
- Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases.
White to off-white powder.
Soluble in DMSO, methanol or water.
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