Anhydrotetracycline hydrochloride 98, Crystalline

Leverancier: Cayman Chemical
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CAYM10009542-50 CAYM10009542-100 CAYM10009542-250
Anhydrotetracycline hydrochloride 98, Crystalline
Anhydrotetracycline hydrochloride

Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.


  • Absorbance: λmax: 224, 272, 428 nm


The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.


Anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet so it does not act as a general inhibitor of translation and is a poor antibiotic. The concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.


Stability: ≥2 years


A crystalline solid

Formule: C₂₂H₂₃ClN₂O₇
MW: 462.883 g/mol
Bewaar temperatuur: Vriezer
MDL Nummer: MFCD00151453
CAS nummer: 13803-65-1

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