2,3',4,5'-Tetramethoxystilbene ≥98%

Leverancier: Cayman Chemical
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Waarschuwing

10038-1 10038-10 10038-5 10038-50
CAYM10038-1EA 25.2 EUR
CAYM10038-1 CAYM10038-10 CAYM10038-5 CAYM10038-50
2,3',4,5'-Tetramethoxystilbene ≥98%
2,3',4,5'-Tetramethoxystilbene

TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.


CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolises both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons.


It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.

Formule: C₁₈H₂₀O₄
Smeltpunt: -99 °C
Bewaar temperatuur: Vriezer
MDL Nummer: MFCD03428621
CAS nummer: 24144-92-1

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