Troglitazone 98 TLC_ASSAY_METHOD

Leverancier: ENZO LIFE SCIENCES
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Total Ratings: 0
Avg. Ratings: 0.0 out of 5

Synoniemen: 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione

BMLGR2100005 BMLGR2100025
ENZOBMLGR2100005EA 165 EUR
ENZOBMLGR2100005 ENZOBMLGR2100025
Troglitazone 98 TLC_ASSAY_METHOD
Troglitazone

PPAR ligand


Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9 µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells.


Synthetic.

Formule: C₂₄H₂₇NO₅S
MW: 441.5 g/mol
MDL Nummer: MFCD00878416
CAS nummer: 97322-87-7
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