XAV939 98 TLC_ASSAY_METHOD
Leverancier: ENZO LIFE SCIENCES
Ratings:
(No Reviews)
Total Ratings: 0
Avg. Ratings: 0.0 out of 5
Synoniemen:
2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, XAV-939
BMLWN1000005
BMLWN1000025
ENZOBMLWN1000005EA
67.1
EUR
ENZOBMLWN1000005
ENZOBMLWN1000025
XAV939 98 TLC_ASSAY_METHOD
XAV939
PARP5a inhibitor
Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
Formule:
C₁₄H₁₁F₃N₂OS MW: 312.3102 g/mol |
MDL Nummer:
MFCD16879017 CAS nummer: 284028-89-3 |
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