BQCA synthetic 97 HPLC_ASSAY_METHOD

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Waarschuwing

Synoniemen: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Benzyl quinolone carboxylic acid.

BMLC1210010 BMLC1210050
ENZOBMLC1210010EA 126 EUR
ENZOBMLC1210010 ENZOBMLC1210050
BQCA synthetic 97 HPLC_ASSAY_METHOD
BQCA

Acetylcholine receptor activator.


Highly selective allosteric potentiator of the M₁ muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M₁ up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100 µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models.


M₁ activators slow the progression of Alzheimer's disease. Induces β-arrestin recruitment to M₁. At 100 µM, it activated M₁ in the absence of ACh to ca. 50% maximal response. At 10 µM, it reduced the concentration of ACh required to displace radioligand by 45-fold. In vivo experiments were carried out in mice at 15 or 20 mg/kg. The compound is cell permeable, brain penetrant and orally active.


Soluble in DMSO (10 mg/ml).

Formule: C₁₈H₁₅NO₄
MW: 309.3 g/mol
MDL Nummer: MFCD01315710
CAS nummer: 338747-41-4

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Specification Test Results

Source Synthetic
Purity ≥97% (HPLC)


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