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Human Hematopoietic Progenitor Cell Expansion Recombinant Protein Bundle (rh SCF, rh FLT-3 Ligand, rh IL-6, rh IL-3) (from E. coli)

Omschrijving: Cytokines for expansion and cell culture of human hematopoietic stem cells to progenitor cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with the decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of SCF, FLT-3 Ligand, IL-6 and IL-3 for short time periods allows rapid expansion of immature and more mature hematopoietic progenitor cells in cord blood or bone marrow preparations. If the goal is to only expand the most immature progenitor and stem cells, it is recommended that a combination of TPO, SCF and FLT-3 Ligand are used (Catalog: PB-500-03). Either cytokine combination can also be supplemented with other cytokines to promote specific lineages.
Catalogus nummer: SHBTPB-500-07
UOM: 1 * 1 Kit
Leverancier: Shenandoah Biotechnology

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Image Unavailable-SHBTPB-500-19

Human Glioma Culture Media Recombinant Protein Bundle (rh EGF, rh FGF-basic 154, rh PDGF-AA, rh PDGF-BB) (from E. coli)

Omschrijving: Cytokines for cell culture of human DIPG and other glioma cells. A glioma is a generic term used to describe tumors that arise from the glia tissue of the brain that supports and surrounds neurons. Diffuse Intrinsic Pontine Glioma (DIPG) is a pediatric brain tumor that originates in the brainstem. Cells isolated from these childhood tumors are successfully cultured ex vivo with EGF, FGF-basic (or FGF-2), and PDGFs (AA and BB).
Catalogus nummer: SHBTPB-500-19
UOM: 1 * 1 Kit
Leverancier: Shenandoah Biotechnology

New Product


Image Unavailable-SHBT100-198-500UG

Human Recombinant PLGF-3 (from E. coli)

Omschrijving: Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.
Catalogus nummer: SHBT100-198-500UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology

New Product


Image Unavailable-SHBT100-198AF-1MG

Human Recombinant PLGF-3 (from E. coli)

Omschrijving: Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.
Catalogus nummer: SHBT100-198AF-1MG
UOM: 1 * 1 mg
Leverancier: Shenandoah Biotechnology

New Product


Image Unavailable-SHBT100-215AF-100U

Human Recombinant FGF-9 (Animal free) (from E. coli)

Omschrijving: Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.
Catalogus nummer: SHBT100-215AF-100U
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology

New Product


Image Unavailable-SHBT800-11AF-500UG

Human/Mouse Recombinant TGF-B 3 (from E. coli)

Omschrijving: Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
Catalogus nummer: SHBT800-11AF-500UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology

New Product


Product Image-SHBT400-10AF-100UG

Pig Recombinant IL-4 (Animal free) (from E. coli)

Omschrijving: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells. GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells. GM-CSF promotes immune system development and regulates neutrophil function during infection.
Catalogus nummer: SHBT400-10AF-100UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-116AF-500U

Human Recombinant VEGF-121 (from E. coli)

Omschrijving: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with one being VEGF-121. The VEGF-121 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell function.
Catalogus nummer: SHBT100-116AF-500U
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
Product Image-SHBT200-37-1MG

Mouse Recombinant GDNF (from E. coli)

Omschrijving: Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.
Catalogus nummer: SHBT200-37-1MG
UOM: 1 * 1 mg
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-136-1MG

Human Recombinant MIP-4 (from E. coli)

Omschrijving: Macrophage inflammatory protein-4 (MIP-4), also called CCL18, is a chemokine expressed in the lymph nodes, lungs, placenta, and bone marrow. MIP-4 receptors include the chemokine receptor 8 (CCR8), the G protein-coupled receptor 30 (GPR30), and the phosphatidylinositol transfer protein membrane-associate 3 (PITPNM3). MIP-4 acts as a chemoattractant for naive T cells, CD4+ T cells, CD8+ T cells, and nonactivated lymphocytes. Further, MIP-4 promotes breast cancer metastasis and attenuates the activation of acute lymphocytic leukemia B cells.
Catalogus nummer: SHBT100-136-1MG
UOM: 1 * 1 mg
Leverancier: Shenandoah Biotechnology
Image Unavailable-SHBT800-07-1MG

Human/Mouse Recombinant TGF-β 3 (from E. coli)

Omschrijving: Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.
Catalogus nummer: SHBT800-07-1MG
UOM: 1 * 1 mg
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-11AF-10UG

Human Recombinant IL-7 (from E. coli)

Omschrijving: Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin 7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.
Catalogus nummer: SHBT100-11AF-10UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-44AF-100UG

Human Recombinant VEGF-165 (Animal free) (from E. coli)

Omschrijving: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.
Catalogus nummer: SHBT100-44AF-100UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-45-500UG

Human Recombinant Prolactin (from E. coli)

Omschrijving: Prolactin is a hormone that is produced and secreted by the pituitary gland. Prolactin acts in an endocrine, paracrine, and autocrine manner. The prolactin receptor (PRLR) is expressed on many cell types, including cells of the reproductive organs, central nervous system, and breast cancer. Prolactin signal transduction occurs via JAK kinase signaling pathways. The primary function of prolactin is to regulate lactation, but prolactin also plays functional roles in the immune system and during cell growth, apoptosis, and differentiation.
Catalogus nummer: SHBT100-45-500UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-46-10UG

Human Recombinant NRG1-B (from E. coli)

Omschrijving: Neuregulin 1-beta (NRG1-β) is one of many alternatively-spliced isoforms of the NRG1 gene and contains a soluble EGF-like domain. The EGF-like domain of NRG1-β signals through the ErbB2, ErbB3, and ErbB4 receptor tyrosine kinases. NRG1-β is an important growth factor involved in neuroinflammation, nerve regeneration, and cardiovascular processes.
Catalogus nummer: SHBT100-46-10UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
Product Image-SHBT100-09AF-500UG

Human Recombinant IL-4 (from E. coli)

Omschrijving: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
Catalogus nummer: SHBT100-09AF-500UG
UOM: 1 * 1 EA
Leverancier: Shenandoah Biotechnology
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