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Catalogus nummer: (PRSI56-625)
Leverancier: ProSci Inc.
Omschrijving: This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin and may function in renal tubular development and function. Mutations in this gene are associated with nephronophthisis type 3. Multiple splice variants have been described but their full-length nature has not been determined.
UOM: 1 * 400 µl

New Product


Catalogus nummer: (PRSI33-333)
Leverancier: ProSci Inc.
Omschrijving: Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
UOM: 1 * 1 EA

New Product


Catalogus nummer: (PRSIXP-5279)
Leverancier: ProSci Inc.
Omschrijving: Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. TARC displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. TARC binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells
UOM: 1 * 1 EA


Leverancier: UVP ULTRA VIOLET PRODUCTS
Omschrijving: UV-veldrek, Met DC-voeding, UV-lichtveldpakket, met DC-voeding, lange golf, fosfor/mantel, lichtlengte: 44,5 mm, Pen-Ray®, 365 nm, Gewicht: 136 g

Catalogus nummer: (PRSI48-226)
Leverancier: ProSci Inc.
Omschrijving: CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces endothelial chemotaxis and may function as an HIV-1 co-receptor on primary human cells, contributing to HIV-1-induced thymic pathogenesis (Lee et al., 2000).
UOM: 1 * 1 EA


Leverancier: WATERS
Omschrijving: Oasis® HLB cartridges contain the Oasis® HLB sorbent, which is a universal polymeric reversed phase sorbent that was developed for the extraction of a wide range of acidic, basic, and neutral compounds from various matrices using a simple, generic protocol.

Catalogus nummer: (PRSI27-217)
Leverancier: ProSci Inc.
Omschrijving: CCR4 belongs to the G-protein-coupled receptor family. It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. The protein encoded by this gene belongs to the G-protein-coupled receptor family. It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1657 BC071751.1 1-1657
UOM: 1 * 1 EA


Catalogus nummer: (PRSI1123)
Leverancier: ProSci Inc.
Omschrijving: Eotaxin Antibody: Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia and eotaxin inhibits the infection of HIV-1.
UOM: 1 * 1 EA


Catalogus nummer: (PRSIXP-5258)
Leverancier: ProSci Inc.
Omschrijving: RANTES is a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. It binds to CCR1, CCR3, CCR4 and CCR5 and is one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV). It is T cell and macrophage specific, induced by mitogens, and belongs to the intercrine beta (chemokine CC) family.
UOM: 1 * 1 EA


Catalogus nummer: (TINT180270)
Leverancier: Lovibond Tintometer
Omschrijving: The Model F is a visual colorimeter designed to optimise the use of Lovibond® glass filters in order to express colourof the sample in terms of Lovibond® Red, Yellow, Blue and Neutral. It can be used for colour measurment of products which transmit light as well as for opaque solids powders and pastes. Typical applications include including fats and fatty oils, bleached lac, liquid chemicals and pharmaceuticals.
UOM: 1 * 1 ST


Leverancier: HUBER
Omschrijving: The low bath volume means these circulators are ideal for controlling the temperature of small external applications, or for direct temperature control of small objects directly in the bath.
The Pilot ONE® controller offers a brilliant 14,5 cm touch screen with graphic functions and a comfortable navigation menu in 11 languages plus USB and Ethernet connections.

Leverancier: Thermo Fisher Scientific
Omschrijving: With these sturdy pumps, a partial vacuum of 86 mbar can be reached very quickly and easily. The vacuum can be controlled with just the index finger. Vacuum is set via a lever on the pump. The pumps reach full pressure with just two priming strokes. Removable cover on exhaust port and trigger to release vacuum, so the pump does not need to be disconnected from the partial vacuum line for venting. Hose connection for standard hoses with 6,4 mm internal diameter. Complete with 60 cm transparent plastic tube.

Environmentally Preferable

Catalogus nummer: (734-1354)
Leverancier: Thermo Fisher Scientific
Omschrijving: PS met bodem dekglas, steriel, met deksel. De CC2™ oppervlaktebehandeling imiteert nauwgezet een biologisch oppervlak gelijkaardig aan poly-D-lysine en is een superieur oppervlak voor hechting en groei van kieskeurige cellen.
UOM: 1 * 30 ST

Environmentally Preferable


Catalogus nummer: (PRSI91-581)
Leverancier: ProSci Inc.
Omschrijving: Mouse CCL24 is a secreted protein, which is a member of the CC chemokine subfamily. Mouse Ccl24 cDNA encodes a 119 amino acid residue precursor protein, shares approximately 58% amino acid sequence identity with human Ccl24. It is predominantly expressed in the jejunum and spleen and also be induced in the lung by allergen challengeand IL4. Mouse ccl24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Ccl24 is chemotactic for resting T-lymphocytes, eosinophils and can bind to CCR3. LPS and IL4 also differentially regulate the expression of Ccl24 in monocytes and macrophages.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI92-100)
Leverancier: ProSci Inc.
Omschrijving: C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.
UOM: 1 * 1 EA


Catalogus nummer: (PRSIXP-5259)
Leverancier: ProSci Inc.
Omschrijving: RANTES is a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. It binds to CCR1, CCR3, CCR4 and CCR5 and is one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV). It is T cell and macrophage specific, induced by mitogens, and belongs to the intercrine beta (chemokine CC) family.
UOM: 1 * 1 EA


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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