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Omschrijving: Tyrosinase is the key enzyme for melanin,synthesis in mammalian melanocytes and has been considered to be a unique marker for the study of melanocyte differentiation. A cDNA library was constructed from poly(A)+ mRNA from mouse melanocytes and screened using anti- tyrosinase antiserum and oligonucleotide probes corresponding to amino acid sequence of tyrosinase. sequencing of some cDNA clones positive in these screenings gave a nucleotide sequence of 1838 nucleotides including a open reading frame of 1344 nucleotides that was found to correspond exactly to the amino acid sequence of the cyanogen bromide fragments of tyrosinase.
Catalogus nummer: BOSSBS-0819R-A555
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: Benzylalcohol, Supelco®
Catalogus nummer: 08421-25ML-F
UOM: 1 * 25 mL
Leverancier: Merck

Omschrijving: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Catalogus nummer: BNC040012-100
UOM: 1 * 100 µl
Leverancier: Biotium


Omschrijving: Aluminium hydroxide, fine powder
Catalogus nummer: 1.01093.9025
UOM: 1 * 25 kg
Leverancier: Merck

MSDS


Omschrijving: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Catalogus nummer: BOSSBS-10454R-A488
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: Methanol, SupraSolv® for gas chromatography, Supelco®
Catalogus nummer: 1.06011.2500
UOM: 1 * 2,5 L
Leverancier: Merck

Omschrijving: Methanol, EMPARTA® ACS analytical reagent, Supelco®
Catalogus nummer: 1.07018.9026
UOM: 1 * 25 L
Leverancier: Merck

MSDS Environmentally Preferable


Omschrijving: Anti-Arginine monomethyl (R-Me) methylate Rabbit Monoclonal Antibody
Catalogus nummer: CSTA8015S
UOM: 1 * 100 µl
Leverancier: Cell Signaling


Omschrijving: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Catalogus nummer: BNCB0012-100
UOM: 1 * 100 µl
Leverancier: Biotium


Omschrijving: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Catalogus nummer: BNC680012-100
UOM: 1 * 100 µl
Leverancier: Biotium


Omschrijving: Methanol, J.T.Baker®
Catalogus nummer: 9049.1000
UOM: 1 * 1 L
Leverancier: Avantor

Omschrijving: Benzylalcohol ≥99.0% analytical reagent
Catalogus nummer: 20807.322
UOM: 1 * 2,5 L
Leverancier: VWR Chemicals

Omschrijving: m-Kresol ≥98%, GPR RECTAPUR®
Catalogus nummer: 23048.261
UOM: 1 * 500 mL
Leverancier: VWR Chemicals

Omschrijving: Methanol ≥98.5%, TECHNICAL
Catalogus nummer: 20903.290
UOM: 1 * 1 L
Leverancier: VWR Chemicals

Omschrijving: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Catalogus nummer: BOSSBS-10454R-A647
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Catalogus nummer: BOSSBS-10454R-A555
UOM: 1 * 100 µl
Leverancier: Bioss


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