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Omschrijving: Macrophage inflammatory protein-1 alpha (MIP-1 alpha), also known as CCL3, is a member of the CC family of chemokines and is most closely related to CCL4 or MIP-1 beta. Mouse MIP-1 alpha signal through CCR1, CCR3, CCR5, and D6 receptors (Menten <i>et al.</i>). MIP-1 alpha exhibits a variety of proinflammatory activities in vitro, including leukocyte chemotaxis, cytokine production, and mast cell activation, and it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo (Cook). MIP-1 alpha plays a critical role in macrophage recruitment into wounds and in tissue repair (DiPietro <i>et al.</i>). It has been demonstrated that blockade of the CCL3/MIP-1 alpha-CCR1 pathway blocks the recruitment of CCR1-expressing CD4+ T cells to the liver, showing a therapeutic potential for treating T cell-mediated liver diseases (Ajuebor <i>et al.</i>).

Catalogus nummer: STMC78089

UOM: 1 * 1 EA

Leverancier: STEMCELL Technologies

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Omschrijving: Human Chemokine (C-C Motif) Ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1, CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid residue precursor protein with a putative 21 amino acid residue signal peptide that is cleaved to generate a 99 amino acid residue mature CCL23 (amino acids 22 -120). Additional N-terminal Processing of the 99 amino acid residue variant can generate a 75 amino acid residue peptide (amino acid 46-120) that is significantly more active than the 99 amino acid residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes, dendritic cells, and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells, but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.

Catalogus nummer: PRSI91-074

UOM: 1 * 1 EA

Leverancier: ProSci Inc.

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Omschrijving: Platelet-Derived Growth Factor Receptor beta (PDGFR- beta ) is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor- alpha and - beta . These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely - alpha alpha, - beta beta and - alpha beta . The extracellular region of the PDGF receptor- beta consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. In addition to being a potent mitogen for cells of mesenchymal origin, PDGF has also been shown to be a potent chemoattractant for mesenchymal cells, mononuclear cells, and neutrophils and has been reported to be important in the modification of cellular matrix constituents.

Catalogus nummer: PRSI91-348

UOM: 1 * 1 EA

Leverancier: ProSci Inc.

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Omschrijving: Anti-CCL4/MIP-1 beta+CCL4L1 Rabbit Monoclonal Antibody [clone: EPR494]

Catalogus nummer: ABCAAB232158-1

UOM: 1 * 1 mg

Leverancier: Abcam

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Omschrijving: Stroombron, Voeding, meervoudige uitgang, DC 0 tot 5, 6, 12 of 30 V / 2,5 A; AC 6, 12, 24 V / 5 A

Catalogus nummer: 139-0394

UOM: 1 * 1 ST

Leverancier: ELC

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Omschrijving: Anti-CCL4/MIP-1 beta Rabbit Monoclonal Antibody [clone: EP521Y]

Catalogus nummer: ABCAAB187674-100

UOM: 1 * 1 EA

Leverancier: Abcam

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Omschrijving: The platelet-derived growth factor (PDGF) family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer (PDGF-AB; Fretto <i>et al.</i>; Li and Eriksson). PDGF signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim <i>et al.</i>). PDGF is a potent mitogen for cells of mesenchymal origin, such as fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto <i>et al.</i>; Sachinidis <i>et al.</i>). PDGF-DD promotes growth and survival of renal artery smooth muscle cells and lens epithelial cells, and can act as a macrophage chemoattractant (Changsirikulchai <i>et al.</i>; Lokker <i>et al.</i>; Ray <i>et al.</i>; Uutela <i>et al.</i>).

Catalogus nummer: STMC78222

UOM: 1 * 1 EA

Leverancier: STEMCELL Technologies

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Omschrijving: Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran <i>et al.</i>). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani <i>et al.</i>). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing <i>et al.</i>; Deshmane <i>et al.</i>). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier <i>et al.</i>).

Catalogus nummer: STMC78087

UOM: 1 * 1 EA

Leverancier: STEMCELL Technologies

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Omschrijving: The platelet-derived growth factor (PDGF) family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer (PDGF-AB; Fretto <i>et al.</i>; Li and Eriksson). PDGF signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim <i>et al.</i>). PDGF is a potent mitogen for cells of mesenchymal origin, such as fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto <i>et al.</i>; Sachinidis <i>et al.</i>). PDGF-BB is secreted by osteoblasts to induce mesenchymal stem cell migration and angiogenesis. It has also been shown that PDGF-BB is secreted by preosteoclasts during bone modeling and remodeling to induce angiogenesis and thus proper osteogenesis (Xie <i>et al.</i>).

Catalogus nummer: STMC78178.1

UOM: 1 * 1 EA

Leverancier: STEMCELL Technologies

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Omschrijving: Thermostaten voor verwarmingscirculatiebaden met baden van roestvrijstaal of polycarbonaat zijn eenvoudig te gebruiken en geschikt voor een groot aantal toepassingen zoals: temperatuurregeling van monsters, analyse, testen van materialen, of het controleren van voedingsmiddelen. De apparaten bieden hoge temperatuurstabiliteit, zijn voorzien van bescherming tegen oververhitting en te laag niveau, voldoen aan veiligheidsklasse III/FL (DIN 12876) en zijn geschikt voor gebruik met ontvlambare vloeistoffen. Een krachtige druk-/aanzuigpomp zorgt voor optimale circulatie en temperatuurverdeling in het bad en voor temperatuurregeling van extern bevestigde toepassingen met behulp van een pompadapter (accessoire). Er is een reeks accessoires verkrijgbaar waaronder inzetstukken, variabele instelbare plateaus, baddeksels, sondes en slangen, vloeistoffen voor temperatuurregeling en verschillende adapters.

Catalogus nummer: HUBE2049.0001.01

UOM: 1 * 1 ST

Leverancier: HUBER

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Omschrijving: Precision Hydrogen series hydrogen generators are suitable for carrier gas and flame gas at standard detection limits. Hydrogen purity: 99,9995%.

Catalogus nummer: 564-0171

UOM: 1 * 1 ST

Leverancier: PEAK SCIENTIFIC

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Omschrijving: CCR5 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

Catalogus nummer: PRSI1112

UOM: 1 * 1 EA

Leverancier: ProSci Inc.

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Omschrijving: Circulatiebadthermostaten met baden vervaardigd van roestvrij staal zijn eenvoudig te gebruiken en geschikt voor een groot aantal toepassingen zoals: temperatuurregeling van monsters, analyse, testen van materialen, of het controleren van voedingsmiddelen. De apparaten bieden hoge temperatuurstabiliteit en zijn voorzien van bescherming tegen oververhitting en te laag niveau en zijn geschikt voor gebruik met ontvlambare vloeistoffen. Een krachtige druk-/aanzuigpomp zorgt voor optimale circulatie en temperatuurverdeling in het bad en voor temperatuurregeling van externe toepassingen met behulp van een pompadapter (accessoire). Er is een reeks optionele accessoires verkrijgbaar waaronder inzetstukken, variabele instelbare plateaus, baddeksels, sondes en slangen, vloeistoffen voor temperatuurregeling en verschillende adapters. Zie www.vwr.com voor meer informatie.

Catalogus nummer: HUBE2058.0001.01

UOM: 1 * 1 ST

Leverancier: HUBER

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Omschrijving: Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has <i>in vitro</i> and <i>in vivo</i> activity similar to neomycin. It is effective against gram-negative bacteria, gram-positive bacteria, some protozoan species, and limited anti helminth. It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit cryptosporidium infection of a human enterocyte cell line.

Catalogus nummer: ICNA0215605625

UOM: 1 * 25 g

Leverancier: MP Biomedicals

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Omschrijving: Anti-CCR5 Rabbit Monoclonal Antibody [clone: EPR23449-327]

Catalogus nummer: ABCAAB280204-100

UOM: 1 * 1 EA

Leverancier: Abcam

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Omschrijving: Macrophage inflammatory protein-1 beta (MIP-1 beta), also known as CCL4, is a member of the CC family of chemokines and is most closely related to CCL3 (MIP-1 alpha). Cellular sources of MIP-1 beta include activated leukocytes (monocytes and T and B cells), brain endothelial cells, and smooth muscle cells (Lukacs <i>et al.</i>; Menten <i>et al.</i>). MIP-1 beta, MIP-1 alpha, and RANTES have been shown to be major HIV-suppressive factors, possibly through the interactions of these chemokines with the receptor CCR5 on CD4+ T cells, which is also a major receptor for HIV entry into CD4+ T cells (Cocchi <i>et al.</i>; Menten <i>et al.</i>). MIP-1 beta attracts a variety of immune cells to sites of microbial infection. In addition to its chemotactic functions, MIP-1 beta induces the release of proinflammatory cytokines, mast cell degranulation, and NK cell activation (Schall <i>et al.</i>). In mice, recruitment of regulatory T cells to B cells and antigen-presenting cells by MIP-1 beta plays a central role in the initiation of T cell and humoral responses, and the depletion of regulatory T cells or MIP-1 beta results in deregulated humoral responses and production of autoantibodies (Bystry <i>et al.</i>).

Catalogus nummer: STMC78091

UOM: 1 * 1 EA

Leverancier: STEMCELL Technologies

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