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Catalogus nummer: (BOSSBS-2615R-A647)
Leverancier: Bioss
Omschrijving: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-1049R-CY5)
Leverancier: Bioss
Omschrijving: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-1049R-CY3)
Leverancier: Bioss
Omschrijving: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-7667R-HRP)
Leverancier: Bioss
Omschrijving: When SLTM is overexpressed it acts as a general inhibitor of transcription that eventually leads to apoptosis.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-0676R-FITC)
Leverancier: Bioss
Omschrijving: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-2615R-HRP)
Leverancier: Bioss
Omschrijving: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-0675R-A350)
Leverancier: Bioss
Omschrijving: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
UOM: 1 * 100 µl


Catalogus nummer: (PROONIST-C2416)
Leverancier: LGC Standards PROMOCHEM
Omschrijving: Lead
UOM: 1 * 1 ST


Catalogus nummer: (BOSSBS-0968R-A350)
Leverancier: Bioss
Omschrijving: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-0009R-A647)
Leverancier: Bioss
Omschrijving: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-0968R-A750)
Leverancier: Bioss
Omschrijving: May be involved in the regulation of dopamine release and transport. Induces fibrillisation of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-0059R-A488)
Leverancier: Bioss
Omschrijving: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-0059R-FITC)
Leverancier: Bioss
Omschrijving: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
UOM: 1 * 100 µl


Catalogus nummer: (BOSSBS-1049R-A350)
Leverancier: Bioss
Omschrijving: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
UOM: 1 * 100 µl


Catalogus nummer: (PROOLGC2608)
Leverancier: LGC Standards PROMOCHEM
Omschrijving: Lead
UOM: 1 * 500 mg


Catalogus nummer: (BOSSBS-9636R-CY7)
Leverancier: Bioss
Omschrijving: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).
UOM: 1 * 100 µl


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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