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Image Unavailable-BTIUBNUM0506-50

Anti-ESR1 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: ER506]

Catalogus nummer: (BTIUBNUM0506-50)
Leverancier: Biotium
Omschrijving: This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.
UOM: 1 * 50 µl
Image Unavailable-BNUM0643-50

Anti-EGFR Mouse Monoclonal Antibody (Purified, BSA-free) [clone: B1D8]

Catalogus nummer: (BNUM0643-50)
Leverancier: Biotium
Omschrijving: This antibody reacts with the extracellular domain of EGFR and blocks the EGF/TGF alpha induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin.
UOM: 1 * 50 µl
Image Unavailable-BNUM0094-50

Anti-PGF Mouse Monoclonal Antibody (Purified, BSA-free) [clone: PLGF94]

Catalogus nummer: (BNUM0094-50)
Leverancier: Biotium
Omschrijving: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
UOM: 1 * 50 µl
Image Unavailable-BNUM0484-50

Anti-PGR Mouse Monoclonal Antibody (Purified, BSA-free) [clone: PR484]

Catalogus nummer: (BNUM0484-50)
Leverancier: Biotium
Omschrijving: This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81 kDa) and PR-B (116 kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.
UOM: 1 * 50 µl
Image Unavailable-BNUM0467-50

Anti-PCNA Mouse Monoclonal Antibody (Purified, BSA-free) [clone: PC10]

Catalogus nummer: (BNUM0467-50)
Leverancier: Biotium
Omschrijving: Recognizes a non-histone protein of 36 kDa, which is identified as proliferating cell nuclear antigen (PCNA). It is also known as cyclin or polymerase delta auxiliary protein. Elevated expression of PCNA/cyclin has been shown in the nucleus during late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases. This MAb is excellent for multiple applications.
UOM: 1 * 50 µl
Image Unavailable-BNUM1057-50

Anti-CD48 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: 5-4.8]

Catalogus nummer: (BNUM1057-50)
Leverancier: Biotium
Omschrijving: Reacts with human CD48, a 45 kDa glycosyl phophatidyl-inositol (GPI)-anchored cell surface protein. CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibroblasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on the patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2.
UOM: 1 * 50 µl
Image Unavailable-BNUM0101-50

Anti-CD4 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: CMV101]

Catalogus nummer: (BNUM0101-50)
Leverancier: Biotium
Omschrijving: Ten to forty percent of the patients with acquired immunodeficiency syndrome (AIDS) develop cytomegalovirus (CMV) infections. In some patients with AIDS, CMV is detected in the bronchoalveolar lavage fluid (BALF), urine, and other specimens, even when there are no symptoms of CMV disease. An indicator of active CMV infection is needed to facilitate the diagnosis of CMV disease in patients with AIDS or HIV infection. CMV p65 antigen was detected in the leukocytes of both the peripheral blood and BALF during the early phase of CMV disease.
UOM: 1 * 50 µl
Image Unavailable-BNUM0751-50

Anti-BCL2L1 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: 2H12]

Catalogus nummer: (BNUM0751-50)
Leverancier: Biotium
Omschrijving: Recognizes a protein of 27 kDa, identified as the Bcl-X protein. This MAb shows no cross-reaction with Bcl-2 or Bax protein. Bcl-X has two isoforms, Bcl-XL (long), a 241 amino acid protein which suppresses cell death. And Bcl-XS (short), a 178 amino acid protein lacking a 63 amino acid domain which functions as a dominant inhibitor of Bcl-2. This MAb reacts with both Bcl-XS and Bcl-XL proteins.
UOM: 1 * 50 µl
Image Unavailable-BNUM0100-50

Anti-CD98 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: CMV100]

Catalogus nummer: (BNUM0100-50)
Leverancier: Biotium
Omschrijving: Ten to forty percent of the patients with acquired immunodeficiency syndrome (AIDS) develop cytomegalovirus (CMV) infections. In some patients with AIDS, CMV is detected in the bronchoalveolar lavage fluid (BALF), urine, and other specimens, even when there are no symptoms of CMV disease. An indicator of active CMV infection is needed to facilitate the diagnosis of CMV disease in patients with AIDS or HIV infection. CMV p65 antigen was detected in the leukocytes of both the peripheral blood and BALF during the early phase of CMV disease.
UOM: 1 * 50 µl
Image Unavailable-BNUM0006-50

Anti-BCL2L1 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: BX006]

Catalogus nummer: (BNUM0006-50)
Leverancier: Biotium
Omschrijving: Recognizes a protein of 27 kDa, identified as the Bcl-X protein. This MAb shows no cross-reaction with Bcl-2 or Bax protein. Bcl-X has two isoforms, Bcl-XL (long), a 241 amino acid protein which suppresses cell death. And Bcl-XS (short), a 178 amino acid protein lacking a 63 amino acid domain which functions as a dominant inhibitor of Bcl-2. This MAb reacts with both Bcl-XS and Bcl-XL proteins.
UOM: 1 * 50 µl
Image Unavailable-BNUM1237-50

Anti-CDKN1B Mouse Monoclonal Antibody (Purified, BSA-free) [clone: SX53G8]

Catalogus nummer: (BNUM1237-50)
Leverancier: Biotium
Omschrijving: This antibody recognizes a 27 kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. Its epitope spans between aa 83-204 of p27. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. p27Kip1 functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. This MAb co-precipitates cdk4 in complex p27Kip1 and is excellent for staining of formalin-fixed tissues.
UOM: 1 * 50 µl
Image Unavailable-BNUM0425-50

Anti-SLC3A2 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: UM7F8]

Catalogus nummer: (BNUM0425-50)
Leverancier: Biotium
Omschrijving: CD98 exits as a heterodimer containing a disulphide-linked glycosylated heavy chain and a non-glycosylated light chain. It is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through disulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.
UOM: 1 * 50 µl
Image Unavailable-BNUM0865-50

Anti-GYPA Mouse Monoclonal Antibody (Purified, BSA-free) [clone: GPHN02]

Catalogus nummer: (BNUM0865-50)
Leverancier: Biotium
Omschrijving: Recognizes a sialoglycoprotein of 39 kDa, identified as glycophorin A (GPA). It is present on red blood cells (RBC) and erythroid precursor cells. It has been shown that glycophorin acts as the receptor for Sandei virus and parvovirus. Glycophorins A (GPA) and B (GPB), which are single, trans-membrane sialoglycoproteins. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation.
UOM: 1 * 50 µl
Image Unavailable-BNUM0120-50

Anti-CD8 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: LSA120]

Catalogus nummer: (BNUM0120-50)
Leverancier: Biotium
Omschrijving: LSA120 MAb is directed against a lung cell antigen. It shows a well-defined reactivity with cells of the lung lineage at all stages of maturation. Non-lung lineages are negative by immuno-histology. Although the exact identity of its antigen has yet to be determined, it has been shown to be distinct from MOC-52 and UM-A9 proteins. This MAb is useful in the identification of normal and neoplastic human lung cells.
UOM: 1 * 50 µl
Image Unavailable-BNUM0004-50

Anti-BAX Mouse Monoclonal Antibody (Purified, BSA-free) [clone: 2D2]

Catalogus nummer: (BNUM0004-50)
Leverancier: Biotium
Omschrijving: Recognizes a protein of 21 kDa, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
UOM: 1 * 50 µl
Image Unavailable-BNUM0232-50

Anti-Phosphotyrosine Mouse Monoclonal Antibody (Purified, BSA-free) [clone: PY20]

Catalogus nummer: (BNUM0232-50)
Leverancier: Biotium
Omschrijving: Protein phosphorylation is a fundamental event in the regulation of a large number of intracellular processes. Phosphorylation of specific tyrosine residues is the result of activation or stimulation of their respective protein tyrosine kinases. The phosphorylated proteins can be auto-phosphorylated kinases or certain cellular protein substrates. Tyrosine-phosphorylated proteins are involved in signal transduction and in the regulation of cell proliferation. Antibody to phosphotyrosine provides an excellent tool for the detection, characterization, and purification of phosphotyrosine containing proteins. This MAb shows no cross-reaction with other phosphoamino acids and is superb for multiple applications including staining of formalin/paraffin tissues.
UOM: 1 * 50 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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