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Product Image-PRSI4779

Anti-IL34 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI4779)
Leverancier: ProSci Inc.
Omschrijving: IL-34 Antibody: Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.
UOM: 1 * 1 EA
Product Image-PRSI3779

Anti-ACTB Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI3779)
Leverancier: ProSci Inc.
Omschrijving: Beta-actin Antibody: Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, beta-actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
UOM: 1 * 1 EA
Image Unavailable-PRSI92-151

Human recombinant NCR3

Catalogus nummer: (PRSI92-151)
Leverancier: ProSci Inc.
Omschrijving: Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumour cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signalling specifically induces lytic activity against several tumour cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
UOM: 1 * 1 EA
Product Image-PRSI6447

Anti-IFLTD1 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI6447)
Leverancier: ProSci Inc.
Omschrijving: IFTLD1 Antibody: The intermediate filament tail domain-containing protein (IFLTD1) was initially identified as a candidate gene for pulmonary adenoma susceptibility 1 gene in mice. Transcripts of the gene were only detected in mouse lung tissue from strains carrying the Pas1-susceptible allele. Expression of different alleles of this gene in lung cancer cell lines resulted in different levels of colony formation in in vitro colony formation assays, suggesting that allelic variants of this gene can modulate growth of human cancer cells.
UOM: 1 * 1 EA
Product Image-PRSIXW-7021

Anti-AKT2 Chicken Polyclonal Antibody

Catalogus nummer: (PRSIXW-7021)
Leverancier: ProSci Inc.
Omschrijving: Murine thymoma viral (v-akt) homolog-2; rac protein kinase beta. AKT2 is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. Furthermore, AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.
UOM: 1 * 1 EA
Product Image-PRSI30-580

Anti-ACPT Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI30-580)
Leverancier: ProSci Inc.
Omschrijving: Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. ACPT has structural similarity to prostatic and lysosomal acid phosphatases.Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
UOM: 1 * 1 EA
Product Image-PRSI28-212

Anti-DIDO1 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI28-212)
Leverancier: ProSci Inc.
Omschrijving: In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. DIDO1 gene is similar to the mouse gene and therefore is thought to be involved in apoptosis.Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.
UOM: 1 * 1 EA
Product Image-PRSI25-497

Anti-TRIM68 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI25-497)
Leverancier: ProSci Inc.
Omschrijving: The protein encoded by TRIM68 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. TRIM68 is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. TRIM68 was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.
UOM: 1 * 1 EA
Image Unavailable-PRSI33-995

Anti-TNF Mouse Monoclonal Antibody [clone: TMDa1-1]

Catalogus nummer: (PRSI33-995)
Leverancier: ProSci Inc.
Omschrijving: Tumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. [UniProt].
UOM: 1 * 1 EA

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Image Unavailable-PRSI91-206

Human recombinant GDNF (from E. coli)

Catalogus nummer: (PRSI91-206)
Leverancier: ProSci Inc.
Omschrijving: Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a disulfide-linked homodimeric glycoprotein that belongs to the TGF- beta superfamily. It has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. Mutations in this gene may be associated with Hirschsprung disease.
UOM: 1 * 1 EA
Image Unavailable-PRSI76-890

Anti-LAMP1 Mouse Monoclonal Antibody [clone: H4A3] (FITC (Fluorescein Isothiocyanate))

Catalogus nummer: (PRSI76-890)
Leverancier: ProSci Inc.
Omschrijving: The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.
UOM: 1 * 1 EA

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Product Image-PRSI6807

Anti-TFCP2L1 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI6807)
Leverancier: ProSci Inc.
Omschrijving: TFCP2L1 Antibody: The Transcription factor CP2-like protein 1 (TFCP2L1) is related to the ubiquitously expressed CP2 family of transcription factors that are generally transcription factors. TFCP2L1 is expressed in a developmentally regulated fashion during embryogenesis and in the epithelial lining of distal convoluted tubules in embryonic and adult kidneys. Recent studies have shown that TFCP2L1 is part of an Oct4-centered protein interaction network in embryonic stem cells. It is thought to modulate the activity of other CP2 family members in a cell specific manner, and is itself regulated by sumoylation at a single major site.
UOM: 1 * 1 EA
Image Unavailable-PRSI92-017

Human recombinant zinc finger 75A (fromE. coli)

Catalogus nummer: (PRSI92-017)
Leverancier: ProSci Inc.
Omschrijving: Zinc Finger Protein 75A (ZNF75A) is a member of krueppel C2H2-type zinc-finger protein family. The human ZNF75 gene is located on Xq26, which has only limited homology (less than 65%) to other ZF genes in the databases. One of these, ZNF75B is a pseudogene mapped to chromosome 12q13. The other two, ZNF75A and ZNF75C, maintain an ORF in the sequenced region, and at least the latter is expressed in the U937 cell line. ZNF75A contains five C2H2-type zinc fingers and one KRAB domain. ZNF75A is a nucleus protein, may involves in transcriptional regulation.
UOM: 1 * 1 EA
Product Image-PRSI5473

Anti-SRPX1 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI5473)
Leverancier: ProSci Inc.
Omschrijving: SRPX1 Antibody: SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
UOM: 1 * 1 EA
Product Image-PRSI56-395

Anti-WNT9A Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI56-395)
Leverancier: ProSci Inc.
Omschrijving: The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.
UOM: 1 * 400 µl

New Product


Product Image-PRSI3777

Anti-ACTB Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI3777)
Leverancier: ProSci Inc.
Omschrijving: Beta-actin Antibody: Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. Beta actin is one of six different actin isoforms which have been identified. Like GAPDH, beta-actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
UOM: 1 * 1 EA
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This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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