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Catalogus nummer: (PRSI90-389)
Leverancier: ProSci Inc.
Omschrijving: CCL24 (eotaxin-2) has been shown to induce chemotaxis of eosinophils, basophils and resting T lymphocytes but not monocytes and activated T lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated levels of CCL24 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI29-589)
Leverancier: ProSci Inc.
Omschrijving: Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 and CEACAM5, and antibodies to both can affect tumor cell growth in vitro and in vivo. CEACAM6 expression is elevated in many solid tumors, but variable as a function of histotype. It may be a promising target for antibody-based therapy.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI91-030)
Leverancier: ProSci Inc.
Omschrijving: GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/macrophages, and eosinophils, GM-CSF has also been reported to have a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI30-397)
Leverancier: ProSci Inc.
Omschrijving: RSU1 is a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the protein was initially isolated based on its ability to inhibit v-Ras transformation.This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI76-888)
Leverancier: ProSci Inc.
Omschrijving: The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.
UOM: 1 * 0,025 mg

New Product


Catalogus nummer: (PRSI33-831)
Leverancier: ProSci Inc.
Omschrijving: This mAb reacts with a carbohydrate determinant, identified as CDw78 (Workshop V; Code CDw78.2). The epitope recognized by this mAb and Leu21 is the same. It is present on some immature and some peripheral blood B cells, and some B cell lines. Its expression is increased after B-cell activation in vitro. CDw78 is also found on tissue macrophages and on epithelial cells, but not on T cells, NK cells, monocytes, granulocytes and myeloid tissues. It appears that CDw78 is a determinant on a major histocompatibility complex (MHC) class II subpopulation.
UOM: 1 * 1 EA

New Product


Catalogus nummer: (PRSI38-194)
Leverancier: ProSci Inc.
Omschrijving: Endostatin, a cleaved product of the C-terminal domain of collagen XVIII, is an endogenous angiogenesis inhibitor. It was originally found in conditioned media from a murine endothelial tumor cell line, hemangioendothelioma. Endostatin inhibits endothelial cell migration (in vivo and in vitro) and induces endothelial cell apoptosis. It inhibits tumor growth and impairs blood vessel maturation in wound healing. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI92-067)
Leverancier: ProSci Inc.
Omschrijving: Tumor Necrosis Factor (TNF) is a member of the Tumor Necrosis Factor family. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI55-642)
Leverancier: ProSci Inc.
Omschrijving: The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis.
UOM: 1 * 400 µl

New Product


Catalogus nummer: (PRSI79-719)
Leverancier: ProSci Inc.
Omschrijving: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
UOM: 1 * 1 EA


Catalogus nummer: (PRSIXW-7955)
Leverancier: ProSci Inc.
Omschrijving: FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
SUBUNIT: LSm subunits form a heteromer with a dougnut shape.
SIMILARITY: Belongs to the snRNP Sm proteins family.
SUBCELLULAR LOCATION: Nuclear (Potential).
TISSUE SPECIFICITY: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI3091)
Leverancier: ProSci Inc.
Omschrijving: AID Antibody: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI76-892)
Leverancier: ProSci Inc.
Omschrijving: The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.
UOM: 1 * 1 EA

New Product


Catalogus nummer: (PRSI76-891)
Leverancier: ProSci Inc.
Omschrijving: The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.
UOM: 1 * 1 EA

New Product


Catalogus nummer: (PRSI91-236)
Leverancier: ProSci Inc.
Omschrijving: Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.
UOM: 1 * 1 EA


Catalogus nummer: (PRSI96-749)
Leverancier: ProSci Inc.
Omschrijving: Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor.
UOM: 1 * 1 EA


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