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Product Image-ENZOBMLPI1260001

CA-074 Me

Catalogus nummer: (ENZOBMLPI1260001)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Potent and selective irreversible cell permeable cathepsin B inhibitor. Methyl ester (Me) is hydrolyzed by intracellular esterases releasing the active inhibitor. Prevents death of CA1 neurons after ischemia following IV delivery after the ischemic insult. In isolated rat osteoclasts it inhibited bone resorption with a maximal effect at 50 µM. This product is only suitable for in vivo and whole cell experiments. The free acid form must be used for in vitro experiments. Can be used to discriminate between cathepsin B and L/S forms.
UOM: 1 * 1 mg
Product Image-734-0230

Multiwellplaten, gecoat met poly-D-lysine/laminine, Corning® BioCoat™

Leverancier: Corning
Omschrijving: PS, coated with mouse laminin. Laminin, a major structural component of basement membranes, has many varied functions that are mediated by binding to various components of the basement membrane (for example, collagen IV) and to cell-surface receptors. Laminin-coated cell culture plates have a number of applications, including the promotion of cell adhesion, proliferation and differentiation of a variety of cell types, particularly neurons, epithelial cells, myocytes and myoblasts.

Certificaten Environmentally Preferable

Image Unavailable-34253-1L

Cerium(IV) sulphate 0,05 M volumetrische oplossing, Fluka™

Catalogus nummer: (34253-1L)
Leverancier: Honeywell Chemicals
Omschrijving: Cerium(IV) sulphate 0,05 M volumetrische oplossing, Fluka™
UOM: 1 * 1 L
Image Unavailable-BOSSBS-1377R-CY5

Anti-MMP-26 Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-1377R-CY5)
Leverancier: Bioss
Omschrijving: Matrix metalloproteinase 26 preprotein; gelatinase A; 70kD type IV collagenase; gelatinase neutrophil. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26 degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodelling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26, also known as Matrilysin 2, was first cloned from human fetal cells, and identified as an MMP most closely related to MMP7 (Matrilysin 1). The homology between MMP7 and MMP26 is low (only 38% identical), thus the functions are unlikely to be similar. Homology is much higher (48% identical) for the comparable region of MMP12, but MMP26 appears to have broader substrate specificity than does MMP12. MMP26, like MMP7, lacks the hemopexin domain common to the other MMPs, but contains a Propeptide domain, cysteine switch activation site, followed by a catalytic domain, and a short vestige of the hinge region. MMP26 is apparently not glycosylated, and is a secreted MMP. Tissue analysis shows MMP26 most strongly in placenta and uterus, but also in kidney cells, lung cells, lymphocytes and lung or endometrial carcinoma cells. MMP26 is proteolytically active, cleaving casein in zymograms, and gelatin, a1PI, fibrinogen, fibronectin, vitronectin, type IV collagen, and apparently activating MMP9.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8510R-CY3

Anti-XRCC4 Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-8510R-CY3)
Leverancier: Bioss
Omschrijving: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
UOM: 1 * 100 µl
Image Unavailable-10727.30

Lood(II)nitraat ≥99.999% (metals basis), Puratronic®

Leverancier: Thermo Fisher Scientific
Omschrijving: Lood(II)nitraat ≥99.999% (metals basis), Puratronic®

MSDS Certificaten

Image Unavailable-BOSSBS-1856R-A350

Anti-MMP16 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-1856R-A350)
Leverancier: Bioss
Omschrijving: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12497R-A555

Anti-APOC2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalogus nummer: (BOSSBS-12497R-A555)
Leverancier: Bioss
Omschrijving: Apolipoproteins are protein components of plasma lipoproteins (1). The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins (2). The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages (3,4). The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues (5–7). The human apoC-III gene maps to chromosome 11q23 and encodes a protein that may delay catabolism of triglyceride-rich particles by inhibiting lipoprotein lipase and hepatic lipase (8). The human apoC-IV gene maps to chromosome 19q13.2 and encodes a 127 amino acid protein that is primarily expressed in the liver (9,10).
UOM: 1 * 100 µl
Image Unavailable-ICNA0215250901

Hexachloroplatinic(IV) acid hexahydrate (37,50% Pt), powder ACS

Leverancier: MP Biomedicals
Omschrijving: Chloroplatinic acid is used in potassium determination, purification of platinum and in catalysis.

Product Image-20284.153

trans-1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid monohydrate ≥99.0%

Catalogus nummer: (20284.153)
Leverancier: VWR Chemicals
Omschrijving: trans-1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid monohydrate ≥99.0%
UOM: 1 * 50 g

MSDS Certificaten


Image Unavailable-BNC940169-500

Anti-CD36 Mouse Monoclonal Antibody (CF594) [clone: 185-1G2]

Leverancier: Biotium
Omschrijving: Recognizes a protein of 80 kDa-90 kDa, identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This MAb blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.

Image Unavailable-BNC550169-100

Anti-CD36 Mouse Monoclonal Antibody (CF555) [clone: 185-1G2]

Leverancier: Biotium
Omschrijving: Recognizes a protein of 80 kDa-90 kDa, identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This MAb blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.

Image Unavailable-BOSSBS-1564R-A350

Anti-Annexin IV Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-1564R-A350)
Leverancier: Bioss
Omschrijving: The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A4 (ANXA4) belongs to the annexin family of calcium dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane related events along exocytotic and endocytotic pathways. ANXA4 has 45 to 59% identity with other members of its family and shares a similar size and exon intron organization. Isolated from human placenta, ANXA4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANXA4 is almost exclusively expressed in epithelial cells.
UOM: 1 * 100 µl
Image Unavailable-ROTHP014.1

Cerium(IV) sulphate tetrahydrate

Catalogus nummer: (ROTHP014.1)
Leverancier: Roth Carl
Omschrijving: Cerium(IV) sulphate tetrahydrate
UOM: 1 * 100 g

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Product Image-AATB13603

TAMRA-cAMP PDE IV substrate "Red Fluorescence"

Catalogus nummer: (AATB13603)
Leverancier: AAT BIOQUEST
Omschrijving: This red cAMP derivative is a specific substrate for phosphodiesterase (PDE) IV.
UOM: 1 * 1 EA
Image Unavailable-BOSSBS-4593R-A350

Anti-MMP9 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-4593R-A350)
Leverancier: Bioss
Omschrijving: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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