U heeft gezocht op: Methotrexate

Leverancier: ENZO LIFE SCIENCES

Omschrijving: Methotrexate

Leverancier: Apollo Scientific

Omschrijving: An antineoplastic agent which acts as an antimetaboliteof folic acid.

Catalogus nummer: (PROOMM0040.00)

Leverancier: LGC Standards PROMOCHEM

Omschrijving: Methotrexate

UOM: 1 * 500 mg

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Catalogus nummer: (PROOICRS0345)

Leverancier: LGC Standards PROMOCHEM

Omschrijving: Methotrexate

UOM: 1 * 100 mg

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Leverancier: Thermo Fisher Scientific

Omschrijving: Methotrexate

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Catalogus nummer: (SANTSC-3507)

Leverancier: Santa Cruz Biotechnology

Omschrijving: Methotrexate

UOM: 1 * 100 mg

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Leverancier: Thermo Fisher Scientific

Omschrijving: Methotrexate hydrate 99%

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Leverancier: TCI

Omschrijving: Methotrexate hydrate ≥98.0% (by HPLC, titration analysis)

Leverancier: MP Biomedicals

Omschrijving: Folic Acid antagonist; structurally similar to folic acid. Methotrexate is a mixture of 4-amino-10-methylfolic acid and closely related compounds.

Catalogus nummer: (J66364.MD)

Leverancier: Thermo Fisher Scientific

Omschrijving: Sodium methotrexate 98.5%

UOM: 1 * 250 mg

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Leverancier: MP Biomedicals

Omschrijving: Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, Methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Catalogus nummer: (00023.)

Leverancier: Biotium

Omschrijving: Fluorescein methotrexate is useful for studying anti-metabolite resistance and spontaneous gene amplification. The dye is actively taken up by cells and binds to dihydrofolate reductase (DHFR) quantitatively.

UOM: 1 * 1 mg

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Catalogus nummer: (PHR1396-1G)

Leverancier: Merck

Omschrijving: Organic Standard, Methotrexate

UOM: 1 * 1 g

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Catalogus nummer: (USBIM3101-01A)

Leverancier: US Biological

Omschrijving: Anti-Methotrexate Goat Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (ENZOENZKIT1420001)

Leverancier: ENZO LIFE SCIENCES

Omschrijving: Ultra sensitive Methotrexate ELISA kit enabling detection of Methotrexate in serum, plasma, and urine in just 1,5 hours.

UOM: 1 * 1 Kit

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Catalogus nummer: (USBIM3101-01D)

Leverancier: US Biological

Omschrijving: Anti-Methotrexate Sheep Polyclonal Antibody

UOM: 1 * 500 µl

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