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Omschrijving: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.
Catalogus nummer: BOSSBS-13308R-HRP
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: Adenosine-5'- diphosphate, disodium salt. Involved in energy and nucleic acid metabolism.
Catalogus nummer: 0160-20G
UOM: 1 * 20 g
Leverancier: VWR Chemicals

MSDS


Omschrijving: 5,6-Diphenyl-3-(2-pyridyl)-1,2,4-triazine-4,4''-disulphonic acid disodium salt hydrate 97+%
Catalogus nummer: ACRO171010010
UOM: 1 * 1 g
Leverancier: Thermo Fisher Scientific

MSDS


Omschrijving: Ammonium carbamate, Supelco®
Catalogus nummer: 1.01134.9050
UOM: 1 * 50 kg
Leverancier: Merck

MSDS


Omschrijving: Fluorescein disodium salt
Catalogus nummer: TCIAF0096-500G
UOM: 1 * 500 g
Leverancier: TCI


Omschrijving: EDTA dipotassium salt dihydrate, Ultrapure
Catalogus nummer: 0720-500G
UOM: 1 * 500 g
Leverancier: VWR Chemicals

Omschrijving: 1-Octaansulfonzuur natriumzout, LiChropur™ for ion pair chromatography, Supelco®
Catalogus nummer: 1.18307.1000
UOM: 1 * 1 kg
Leverancier: Merck

Omschrijving: Members of the EF-CBP (N-terminal EF-hand calcium binding protein)/NECAB (neuronal calcium-binding protein) family participate in neuronal calcium signaling. EF-CBP2, also known as NECAB2 (N-terminal EF-hand calcium binding protein 2), neuronal calcium-binding protein 2 or synaptotagmin-interacting protein 2 (Stip-2), is a 386 amino acid cytoplasmic protein that contains one antibiotic biosynthesis monooxygenase (ABM) domain and two EF-hand domains. Expressed in brain, EF-CBP2 is suggested to bind metabotropic glutamate receptor 5 (mGluR-5) in a calcium-regulated manner. The gene encoding EF-CBP2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Catalogus nummer: BOSSBS-9016R-A555
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: Members of the EF-CBP (N-terminal EF-hand calcium binding protein)/NECAB (neuronal calcium-binding protein) family participate in neuronal calcium signaling. EF-CBP2, also known as NECAB2 (N-terminal EF-hand calcium binding protein 2), neuronal calcium-binding protein 2 or synaptotagmin-interacting protein 2 (Stip-2), is a 386 amino acid cytoplasmic protein that contains one antibiotic biosynthesis monooxygenase (ABM) domain and two EF-hand domains. Expressed in brain, EF-CBP2 is suggested to bind metabotropic glutamate receptor 5 (mGluR-5) in a calcium-regulated manner. The gene encoding EF-CBP2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Catalogus nummer: BOSSBS-9016R-CY7
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.
Catalogus nummer: BOSSBS-13306R-CY5
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.
Catalogus nummer: BOSSBS-13306R-CY3
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: 4-Dimethylaminobenzenediazosulphonic acid sodium salt ≥97.0% (by HPLC, titration analysis)
Catalogus nummer: TCIAD1394-5G
UOM: 1 * 5 g
Leverancier: TCI


Omschrijving: α-Ketoglutaric acid monosodium salt 98%
Catalogus nummer: ACRO439350050
UOM: 1 * 5 g
Leverancier: Thermo Fisher Scientific

MSDS


Omschrijving: Nitrilotriacetic acid disodium salt ≥99.0% (by titrimetric analysis)
Catalogus nummer: TCIAN0100-25G
UOM: 1 * 25 g
Leverancier: TCI


Omschrijving: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Catalogus nummer: BOSSBS-1133R-HRP
UOM: 1 * 100 µl
Leverancier: Bioss


Omschrijving: 1-Naphthyl phosphate disodium salt substrate for Phosphatase
Catalogus nummer: TCIAP0263-5G
UOM: 1 * 5 g
Leverancier: TCI

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