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Product Image-PRSI3783

Anti-GAPDH Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI3783)
Leverancier: ProSci Inc.
Omschrijving: GAPDH Antibody: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer's and Huntington's disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
UOM: 1 * 1 EA
Product Image-PRSI4345

Anti-CDNF Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI4345)
Leverancier: ProSci Inc.
Omschrijving: CDNF Antibody: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.
UOM: 1 * 1 EA
Product Image-PRSI3405

Anti-BCL2L11 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI3405)
Leverancier: ProSci Inc.
Omschrijving: Bim Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
UOM: 1 * 1 EA
Image Unavailable-PRSI90-524

Mouse recombinant IL22 (from E. coli)

Catalogus nummer: (PRSI90-524)
Leverancier: ProSci Inc.
Omschrijving: Interleukin-22 (IL-22), also known as IL-10 related T cell-derived-inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
UOM: 1 * 1 EA
Image Unavailable-PRSI33-720

Anti-IFNA2 Mouse Monoclonal Antibody [clone: N27]

Catalogus nummer: (PRSI33-720)
Leverancier: ProSci Inc.
Omschrijving: Recognises a protein of 16-27 kDa, identified as human Interferon alpha 2 (IFNA2). Its epitope maps between amino acids 43-53 of the IFNA2. This mAb is specific for IFNA2 and does not cross-react with IFNA1. The epitopes of clones N27 and N39 mAbs are different and represent a good combination of antibodies to set up an ELISA assay for the quantitation of IFNA2 after viral infections. The IFNA family consists of 24 or more genes or pseudo-genes. The alpha interferons are mainly produced by lymphocytes, monocytes, macrophages, and cell lines such as Namalwa and KG1 following induction by viruses, nucleic acids, and glucocorticoid hormones. They are involved in virus resistance on target cells, inhibition of cell proliferation, induction of cytokines and regulation of expression of MHC class I antigens.
UOM: 1 * 1 EA

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Image Unavailable-PRSI33-106

Anti-CDC20 Mouse Monoclonal Antibody [clone: AR12]

Catalogus nummer: (PRSI33-106)
Leverancier: ProSci Inc.
Omschrijving: Cyclins, regulatory subunits which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 kinase (p34Cdc2) exhibits kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested.
UOM: 1 * 1 EA

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Image Unavailable-BOSSBS-10366R-A680

Anti-MYPN Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-10366R-A680)
Leverancier: Bioss
Omschrijving: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10366R-A488

Anti-MYPN Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalogus nummer: (BOSSBS-10366R-A488)
Leverancier: Bioss
Omschrijving: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2609R-A350

Anti-IL17B Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-2609R-A350)
Leverancier: Bioss
Omschrijving: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2609R-A555

Anti-IL17B Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalogus nummer: (BOSSBS-2609R-A555)
Leverancier: Bioss
Omschrijving: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
UOM: 1 * 100 µl
Product Image-PRSI4353

Anti-LGP2 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI4353)
Leverancier: ProSci Inc.
Omschrijving: LGP2 Antibody: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
UOM: 1 * 1 EA
Product Image-BOSSBS-1710R

Anti-CCR10 Rabbit Polyclonal Antibody

Catalogus nummer: (BOSSBS-1710R)
Leverancier: Bioss
Omschrijving: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
UOM: 1 * 100 µl
Product Image-PRSI96-609

Human recombinant PD15 (from HEK293 cells)

Catalogus nummer: (PRSI96-609)
Leverancier: ProSci Inc.
Omschrijving: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
UOM: 1 * 1 EA
Image Unavailable-PRSI33-573

Anti-PECAM1 Mouse Monoclonal Antibody [clone: C31.12]

Catalogus nummer: (PRSI33-573)
Leverancier: ProSci Inc.
Omschrijving: CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 mAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
UOM: 1 * 1 EA

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Product Image-PRSI2227

Anti-DEDAF Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI2227)
Leverancier: ProSci Inc.
Omschrijving: DEDAF Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor. DEDAF is identical to the transcriptional repressor RYBP. DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.
UOM: 1 * 1 EA
Image Unavailable-PRSI34-151

Anti-PECAM1 Mouse Monoclonal Antibody [clone: SPM532]

Catalogus nummer: (PRSI34-151)
Leverancier: ProSci Inc.
Omschrijving: CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 mAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
UOM: 1 * 1 EA

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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