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Catalogus nummer: (BOSSBS-6313R-BF647)

Leverancier: Bioss

Omschrijving: Aldehydic products of lipid peroxidation, such as 4 hydroxynonenal (4 HNE), have been implicated in the etiology of pathological changes under oxidative stress as a key mediator of oxidative stress induced cell death. It is a stable product of lipid peroxidation, is proarrhythmic and may contribute to the cytotoxic effects of oxidative stress 4-HNE has been hypothesised to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-1976R)

Leverancier: Bioss

Omschrijving: Anti-MATN1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-2007R-CY7)

Leverancier: Bioss

Omschrijving: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-11770R-A350)

Leverancier: Bioss

Omschrijving: Anti-TMEM158 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-12201R)

Leverancier: Bioss

Omschrijving: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-12367R)

Leverancier: Bioss

Omschrijving: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-1574R)

Leverancier: Bioss

Omschrijving: Provides the precursors necessary for DNA synthesis. catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-1409R)

Leverancier: Bioss

Omschrijving: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-7511R)

Leverancier: Bioss

Omschrijving: Potent vasoconstrictor.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-1385R)

Leverancier: Bioss

Omschrijving: Anti-ADAMTS12 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-0747R)

Leverancier: Bioss

Omschrijving: Anti-RANKL Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-1373R)

Leverancier: Bioss

Omschrijving: Anti-NGAL/Lipocalin 2 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-0780R)

Leverancier: Bioss

Omschrijving: Anti-CXCL8 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-9705R)

Leverancier: Bioss

Omschrijving: Anti-ITM2A Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-0876R)

Leverancier: Bioss

Omschrijving: Anti-AKT1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-0437R)

Leverancier: Bioss

Omschrijving: Anti-Streptavidin Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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