Omschrijving: SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.

Catalogus nummer: BOSSBS-11784R

UOM: 1 * 100 µl

Leverancier: Bioss

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Omschrijving: SPR, also known as sepiapterin reductase, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family. SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives. In addition, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the final reduction step of the synthesis pathway. BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine) and is required for proper dopamine synthesis. Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, a monoamine neurotransmitter deficiency without hyperphenylalaninemia. Sepiapterin reductase deficiency interferes with BH4 synthesis, resulting in DOPA-responsive dystonia and a variety of other human diseases. In addition, SPR mRNA expression is increased in the brain of Parkinson’s Disease (PD) patients, suggesting that SPR may play a role in PD.

Catalogus nummer: BOSSBS-11784R-FITC

UOM: 1 * 100 µl

Leverancier: Bioss

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Omschrijving: Tyrosine hydroxylase is an excellent marker for dopaminergic and noradrenergic neurons. Tyrosine hydroxylase (a.k.a. tyrosine 3-monooxygenase) is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). http://en.wikipedia.org/wiki/Tyrosine_hydroxylase

Catalogus nummer: BSENM-1616-100

UOM: 1 * 100 µl

Leverancier: Biosensis

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Omschrijving: SYAP1 (synapse-associated protein 1) is a 352 amino acid protein that is ubiquitously expressed in adult tissues. SYAP1 contains one BSD domain which is a novel domain that is present in basal transcription factors, synapse-associated proteins and several hypothetical proteins. The BSD domain is characterised by three predicted alpha helices and by conserved tryptophan and phenylalanine residues, located at the C-terminus of the domain. The gene that encodes SYAP1 in humans is located on chromosome X. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome.

Catalogus nummer: BOSSBS-0121R-A680

UOM: 1 * 100 µl

Leverancier: Bioss

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Omschrijving: SYAP1 (synapse-associated protein 1) is a 352 amino acid protein that is ubiquitously expressed in adult tissues. SYAP1 contains one BSD domain which is a novel domain that is present in basal transcription factors, synapse-associated proteins and several hypothetical proteins. The BSD domain is characterised by three predicted alpha helices and by conserved tryptophan and phenylalanine residues, located at the C-terminus of the domain. The gene that encodes SYAP1 in humans is located on chromosome X. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome.

Catalogus nummer: BOSSBS-0121R-A750

UOM: 1 * 100 µl

Leverancier: Bioss

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Omschrijving: SYAP1 (synapse-associated protein 1) is a 352 amino acid protein that is ubiquitously expressed in adult tissues. SYAP1 contains one BSD domain which is a novel domain that is present in basal transcription factors, synapse-associated proteins and several hypothetical proteins. The BSD domain is characterized by three predicted alpha helices and by conserved tryptophan and phenylalanine residues, located at the C-terminus of the domain. The gene that encodes SYAP1 in humans is located on chromosome X. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome.

Catalogus nummer: BOSSBS-0121R-FITC

UOM: 1 * 100 µl

Leverancier: Bioss

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Omschrijving: Anti-Tryptophan Hydroxylase/TPH Rabbit Polyclonal Antibody

Catalogus nummer: ANTIA13512-100

UOM: 1 * 100 µl

Leverancier: ANTIBODIES.COM

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Omschrijving: Human Tryptophan Hydroxylase/TPH ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human Tryptophan Hydroxylase/TPH in serum, plasma, and other biological fluids.

Catalogus nummer: ANTIA312853-96

UOM: 1 * 1 EA

Leverancier: ANTIBODIES.COM

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Omschrijving: Human Tryptophan Hydroxylase/TPH ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human Tryptophan Hydroxylase/TPH in serum, plasma, tissue homogenates, and other biological fluids.

Catalogus nummer: ANTIA78909-96

UOM: 1 * 1 EA

Leverancier: ANTIBODIES.COM

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Omschrijving: The tetramer binds two molecules of protoheme IV. It is a homotetramer involved in tryptophan catabolism. There is a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.

Catalogus nummer: PRSIXW-RP3263

UOM: 1 * 1 EA

Leverancier: ProSci Inc.

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Omschrijving: Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.

Catalogus nummer: PRSI26-070

UOM: 1 * 1 EA

Leverancier: ProSci Inc.

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Omschrijving: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.

Catalogus nummer: BOSSBS-10125R-HRP

UOM: 1 * 100 µl

Leverancier: Bioss

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Omschrijving: Rabbit IgG polyclonal antibody for Tryptophan Hydroxylase detection. Tested with WB, Direct ELISA in Human;Mouse;Rat.

Catalogus nummer: BSBTA01626-1

UOM: 1 * 1 EA

Leverancier: Boster Bio

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Omschrijving: Anti-PWP2 Rabbit Polyclonal Antibody

Catalogus nummer: USBI040699

UOM: 1 * 200 µl

Leverancier: US Biological

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Omschrijving: Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyses the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.

Catalogus nummer: PRSI92-161

UOM: 1 * 1 EA

Leverancier: ProSci Inc.

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Omschrijving: Anti-Tryptophan Hydroxylase pS58 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 53 kDa in size corresponding to tryptophan hydroxylase protein.

Catalogus nummer: ROCK600-401-C97

UOM: 1 * 100 µl

Leverancier: Rockland Immunochemicals

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