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Catalogus nummer: (STMC100-1459)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal antibody against human IFN-gamma, FITC-conjugated.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1598)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal antibody against mouse CD45.2, APC-conjugated.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1454)

Leverancier: STEMCELL Technologies

Omschrijving: Rat monoclonal antibody against human IL-4, unconjugated.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1619)

Leverancier: STEMCELL Technologies

Omschrijving: Rat monoclonal antibody against mouse IL-4, PE-conjugated.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1460)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal antibody against human IFN-gamma, unconjugated.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1465)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal antibody against human, cynomolgus IL-2.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1616)

Leverancier: STEMCELL Technologies

Omschrijving: Hamster (Armenian) monoclonal antibody against mouse CD69, PE-conjugated.

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-1081)

Leverancier: STEMCELL Technologies

Omschrijving: Goat polyclonal antibody against mouse IgG (H+L).

UOM: 1 * 1 EA

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Catalogus nummer: (STMC100-0520)

Leverancier: STEMCELL Technologies

Omschrijving: Serum-free differentiation kit for the generation of hepatocyte-like cells from human PSCs.

UOM: 1 * 1 Kit

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Leverancier: STEMCELL Technologies

Omschrijving: Betacellulin is a member of the epidermal growth factor (EGF) family, and signals through EGF receptor and ERBB4. It activates ERK and AKT pathways, which induces neural stem cell proliferation and prevents spontaneous differentiation in culture. Betacellulin stimulates the expansion of neural stem cells, transit-amplifying cells, and neuroblasts derived from subventricular zone and dentate gyrus (Gómez-Gaviro <i>et al.</i>). It is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin down-regulates E-cadherin expression in ovarian cancer cell lines via MEK/ERK1/2 and PI3K/AKT signaling pathways, thus increasing cell migration (Zhao <i>et al.</i>). It is a modulator of interferon (IFN) response and enhances anti-viral effects of IFN (Al-Yahya <i>et al.</i>). Betacellulin is expressed in pancreatic α cells, β cells, and duct cells. It induces the proliferation of pancreatic cancer cell lines, inhibits apoptosis, promotes the neogenesis of β cells, and converts non-β cells into insulin-producing cells (Kawaguchi <i>et al.</i>; Miyagawa al.; Saito <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knots (Treanor <i>et al.</i>). GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase (Durbec <i>et al.</i>). Four different forms of GFRα co-receptors have been characterized (GFRα 1-4); GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen and Saarma). GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both <i>in vivo</i> and in vitro studies and increases their high-affinity dopamine uptake (Granholm <i>et al.</i>; Lin <i>et al.</i>). GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins (Aoi <i>et al.</i>). GDNF, together with Human Recombinant BDNF (brain-derived neurotrophic factor), BrainPhys™ Neuronal Medium, and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Bardy <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: GRO (growth-regulated oncogene)-beta or CXCL2 is a member of the CXC family, which plays an integral role in recruitment and activation of neutrophils and basophils in response to tissue injury and microbial infection. GRO-beta and GRO-gamma are closely related to GRO-alpha and share 90% and 86% amino acid sequence homology, respectively, with GRO-alpha. Receptor-binding studies have demonstrated that GRO-alpha, -beta, and -gamma signal mainly through G protein-coupled receptors CXCR1 and CXCR2 (Ahuja and Murphy). GRO-beta is expressed in epithelial cells, monocytes, fibroblasts, and melanocytes and is further induced during inflammatory, epithelialization, and angiogenic processes, for example during the wound healing process of human burn wounds (Zaja-Milatovic and Richmond). GRO-beta also stimulates mitogenesis in certain human melanoma cells (Unemori <i>et al.</i>).

Catalogus nummer: (STMC78104.1)

Leverancier: STEMCELL Technologies

Omschrijving: Amphiregulin is a member of the epidermal growth factor (EGF) family. It binds to several receptors including EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3, and HER4/ErbB4, which activates Ras/Raf/MAPK and PI3K/AKT pathways. This results in cell proliferation, apoptosis resistance, and invasive behaviour (Normanno <i>et al.</i>). The expression of amphiregulin is induced by tissue injury and inflammation. Amphiregulin promotes mammary development, trophoblast growth, lung and kidney branching morphogenesis, and keratinocyte proliferation. It stimulates the growth of most cell types, including normal and transformed mammary epithelial cells, and malignant cells of the colon, prostate, cervix, and pancreas (Berasain and Avila).

UOM: 1 * 1 EA

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Leverancier: STEMCELL Technologies

Omschrijving: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello <i>et al.</i>). BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson <i>et al.</i>). It is expressed in the hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle <i>et al.</i>). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, and contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell line-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman).

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic positive selection of human cells labeled with PE-conjugated antibodies.