U heeft gezocht op: STEMCELL Technologies

Catalogus nummer: (STMC03804)

Leverancier: STEMCELL Technologies

Omschrijving: Semi-solid methylcellulose-based medium for hybridoma selection and cloning, with HAT (serum-containing).

UOM: 1 * 90 mL

Sale

 This is a MarketSource item. Additional charges may apply

Catalogus nummer: (STMC03805)

Leverancier: STEMCELL Technologies

Omschrijving: Hybridoma growth medium with hypoxanthine and thymidine (serum-containing).

UOM: 1 * 500 mL

Sale

 This is a MarketSource item. Additional charges may apply

Leverancier: STEMCELL Technologies

Omschrijving: Serum-free cryopreservation medium for human ES and iPS cells.

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic isolation of CD4+ T cells directly from whole blood

Leverancier: STEMCELL Technologies

Omschrijving: Interleukin 13 (IL-13) is a type I cytokine, and signals through type I cytokine receptors to activate JAK/STAT and IRS-1/IRS-2 pathways. IL-13 is produced by T cells and innate lymphoid cells (Pulendran and Artis) and it inhibits production of pro-inflammatory cytokines, prostaglandins, and reactive oxygen and nitrogen species by monocytes and macrophages (Hershey). Unlike human B cells, IL-13 has no effect on mouse B cell development and function. IL-13 promotes eosinophil survival, activation, and recruitment, and also activates mast cells (Hershey). IL-13 regulates gastrointestinal parasite expulsion, airway hyperresponsiveness, allergic inflammation, tissue eosinophilia, goblet cell hyperplasia, intracellular parasitism, tissue remodeling, tumor cell growth, and fibrosis. IL-13 induces hypercontractility of smooth muscles by directly acting on the muscle cells as well as the enteric nerves (Wynn).

Catalogus nummer: (STMC60043)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG2a antibody against human CD51 (integrin αV), unconjugated.

UOM: 1 * 1 EA

Sale

 This is a MarketSource item. Additional charges may apply

Catalogus nummer: (STMC60013)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG1 antibody against human CD34, unconjugated.

UOM: 1 * 1 EA

Sale

 This is a MarketSource item. Additional charges may apply

Catalogus nummer: (STMC60039)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin), unconjugated.

UOM: 1 * 1 EA

Sale

 This is a MarketSource item. Additional charges may apply

Leverancier: STEMCELL Technologies

Omschrijving: Rat monoclonal IgG1, kappa isotype control antibody, biotin-conjugated.

Leverancier: STEMCELL Technologies

Omschrijving: Rat monoclonal IgM, kappa isotype control antibody, FITC-conjugated.

Leverancier: STEMCELL Technologies

Omschrijving: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit <i>et al.</i>), the activation of metalloproteases that cleave VCAM-1 (Levesque <i>et al.</i>), and the release of norepinephrine from the sympathetic nervous system (Katayama <i>et al.</i>), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Mouse G-CSF was first purified from cultures of the WEHI-3B myelomonocytic leukemia cell line as the inducer of the terminal differentiation of WEHI-3B and other myeloid leukemia cell lines (Nicola <i>et al.</i>). It was later cloned in monkey COS cells from a cDNA library prepared with mRNA derived from mouse fibrosarcoma NFSA cells that produce G-CSF constitutively (Tsuchiya <i>et al.</i>). Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways.

Leverancier: STEMCELL Technologies

Omschrijving: Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch and Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and <i>in vivo</i> (Finch and Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin <i>et al.</i>). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag <i>et al.</i>) and to induce autophagy in human keratinocytes (Belleudi <i>et al.</i>). Additionally, FGF-7 has a role in pluripotent stem cell differentiation to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami <i>et al.</i>; Niu <i>et al.</i>).

Catalogus nummer: (STMC60158)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD25, unconjugated.

UOM: 1 * 1 EA

Sale

 This is a MarketSource item. Additional charges may apply

Leverancier: STEMCELL Technologies

Omschrijving: Heregulin-beta 1 also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases (Britsch <i>et al.</i>). Heregulin/neuregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3, and NRG4). Heregulin-beta 1 plays an important role during the development of the nervous system, heart, and mammary glands (Britsch). Heregulin-beta 1 is expressed in neuronal cells, and modulates cell growth and differentiation of the cells during development and wound healing (Mei and Xiong). It has been implicated through in vivo and in vitro studies that heregulin-beta 1/ErbB signaling is crucial for multiple aspects of cardiovascular development and protects the heart from ischemic injury (Odiete <i>et al.</i>). Heregulin-beta 1 also promotes invasiveness and metastasis of breast cancer cells (Hutcheson <i>et al.</i>). It has also been shown that heregulin-beta 1 has a role in the growth and maintenance of human embryonic stem cells (Wang <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to the ST2 receptor and activates NF-kB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz <i>et al.</i>; Yasuda <i>et al.</i>). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections (Liew; Yasuda <i>et al.</i>). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds. Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells, macrophages, and CD4+ T cells, as well as mast cells, NK cells, neutrophils, and B cells, under specific stimulating conditions (Saraiva and O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes, and is important for the function of regulatory T cells. IL-10 also enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression, while IL-10 produced by macrophages inhibits activation of neighboring macrophages, thus allowing a level of self-regulation (Ouyang <i>et al.</i>).