U heeft gezocht op: Tonbo Biosciences

Catalogus nummer: (70-8030-M002)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Human IgM (mu chain) - Affinity Pure, min x w/human IgA + IgG

UOM: 1 * 2 mg

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Catalogus nummer: (30-8117-M001)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Human IgA (alpha chain) - Affinity Pure, Biotin Conjugate, min x w/bovine, mouse, and rabbit serum proteins

UOM: 1 * 1 mg

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Catalogus nummer: (70-8042-M002)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Mouse IgG (H&L) - Affinity Pure

UOM: 1 * 2 mg

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Catalogus nummer: (70-8075-M001)

Leverancier: Tonbo Biosciences

Omschrijving: Rabbit anti-Human IgM (mu chain) - Affinity Pure

UOM: 1 * 1 mg

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Catalogus nummer: (72-8042-M001)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalogus nummer: (35-8065-M002)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate

UOM: 1 * 2 mg

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Catalogus nummer: (35-8068-M001)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum

UOM: 1 * 1 mg

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Catalogus nummer: (35-8066-M002)

Leverancier: Tonbo Biosciences

Omschrijving: Goat anti-Mouse IgM (mu chain) - Affinity Pure, FITC Conjugate, min x w/human IgG or serum proteins

UOM: 1 * 2 mg

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Catalogus nummer: (35-8077-M002)

Leverancier: Tonbo Biosciences

Omschrijving: Rabbit anti-Mouse IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/human serum proteins

UOM: 1 * 2 mg

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Leverancier: Tonbo Biosciences

Omschrijving: The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation. The 2H7 antibody is reported to be cross-reactive with several non-human species including Baboon, Chimpanzee, Cynomolgus and Rhesus. Please choose the appropriate format for each application.

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Omschrijving: The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will "compete" for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.

Leverancier: Tonbo Biosciences

Omschrijving: The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). These receptors are expressed by B cells, monocytes, macrophages, NK cells, dendritic cells, and neutrophils.

Leverancier: Tonbo Biosciences

Omschrijving: The RPA-2.10 antibody reacts with human CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD58 in the human and is expressed on the cell surface of 80-90% of human peripheral blood lymphocytes, a subset of NK cells, and all mature T cells. CD2 mediates lymphocyte adhesion and is involved in T cell activation.

Leverancier: Tonbo Biosciences

Omschrijving: The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO.

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Omschrijving: The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

Leverancier: Tonbo Biosciences

Omschrijving: The SK1 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.