Anti-KLF1 Rabbit Polyclonal Antibody

Leverancier: Bioss
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BS-9526R
BOSSBS-9526REA 725 EUR
BOSSBS-9526R
Anti-KLF1 Rabbit Polyclonal Antibody
Antilichamen
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor byMore Product Information
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