U heeft gezocht op: Diammonium+oxalate

Omschrijving: The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.

Catalogus nummer: ENZOADI905780100

UOM: 1 * 1 EA

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Omschrijving: Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both seven-transmembrane domain-containing GPCRs. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following injury. B2 receptors signal via Gq alpha subunits, leading to activation of phospholipase Cbeta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.

Catalogus nummer: ENZOADI905747100

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Omschrijving: Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing G-protein coupled receptor (GPCR) family A, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 dopamine receptors are encoded by homologous intron-containing genes, and signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity, as well as modulate cellular ion channel conductance of K+ and Ca2+. This is in contrast to D1 and D5 dopamine receptors, which signal via Gs alpha subunits to activate adenylyl cyclase activity. Coactivation of D1 and D2 receptors has been shown to activate a Gq mediated pathway, stimulating phospholipase C (PLC) and mobilizing intracellular calcium stores. D1 receptors were initially characterized in the striatum and retina and are expressed throughout the brain in the olfactory tubercle, islands of Calleja, entopeduncular nucleus, neocortex, hippocampus, and amygdala. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.

Catalogus nummer: ENZOADI905789100

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Omschrijving: Prostaglandin F2alpha (PGF2alpha) is formed in a variety of cells from PGH2, which itself is synthesized from arachidonic acid by the enzyme prostaglandin synthetase. PGF2alpha is often viewed as an antagonist to PGE2 due to their opposing effects on various tissues. PGF2alpha is a potent bronchoconstrictor and has been implicated in asthma attacks. PGF2alpha is also involved in reproductive functions including corpus luteum regulation, uterine contractions, and sperm motility. This has led to its use in terminating pregnancies and inducing labor at term. High levels of PGF2alpha have also been associated with preeclampsia.

Catalogus nummer: ENZOADI905016100

UOM: 1 * 100 µl

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Omschrijving: HETEs are byproducts generated by the metabolism of arachidonic acid by lipoxygenases. 12(S)-HETE is the stereospecific hydroxy product from the reduction of 12(S)-hydroperoxy tetraenoic eicosatetraenoic acid [12(S)-HpETE], which itself is a 12-lipoxygenase metabolite of arachidonic acid. 12(S)-HETE is chemotactic and chemokinetic for polymorphonuclear leukocytes and vascular smooth muscle cells. It also acts as a second messenger in angiotensin-II induced aldosterone production. 15-hydroxyeicosatetraenoic acid [15(S)-HETE] is the major hydroxy derivative of arachidonic acid when acted upon by 15-lipoxygenase. It is also the primary monohydroxy acid synthesized by the lipoxygenase activity of Cyclooxygenase-1 upon linoleic acid. 15(S)-HETE acts as a paracrine regulator of smooth muscle and lung neutrophil recruitment, and elevated levels of 15(S)-HETE are associated with asthma, rhinitis, chronic paranasal sinusitis and rheumatoid arthritis.

Catalogus nummer: ENZOADI905053100

UOM: 1 * 100 µl

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Omschrijving: APRIL (A proliferation-inducing ligand) is a member of the TNF family. APRIL stimulates B- and T-cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death.

Catalogus nummer: ENZOADICSA836E

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Omschrijving: Hsp60 is a member of the chaperonin family of heat shock proteins, with homologs functioning in the cytosol and mitochondria to fold nascent and aggregated proteins. Hsp60 is the eukaryotic homolog of the E. coli GroEL protein, and forms a multimeric complex in the mitochondria with Hsp10 (Cpn10) to form a large central cavity in which ATP-dependent protein folding takes place. TRiC/CCT, a eukaryotic relative of Hsp60, is expressed in the cytosol and participates in the folding of actin and tubulin substrates, but lacks any association with an Hsp10-like co-factor.

Catalogus nummer: ENZOADISPA807E

UOM: 1 * 1 EA

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Omschrijving: Produced in <i>E. coli</i>.

Catalogus nummer: ENZOADISPP540200

UOM: 1 * 1 EA

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Omschrijving: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Catalogus nummer: ENZOADISPA896F

UOM: 1 * 1 EA

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Omschrijving: Produced in <i>E. coli</i>.

Catalogus nummer: ENZOADISPP502D

UOM: 1 * 1 EA

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Omschrijving: Produced in <i>E. coli</i>.

Catalogus nummer: ENZOALX201178C100

UOM: 1 * 1 EA

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Omschrijving: Produced in <i>E. coli</i>. Full length human NMNAT3 is fused at the N-terminus to a His-tag.

Catalogus nummer: ENZOALX201238C100

UOM: 1 * 1 EA

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Omschrijving: Produced in SF21 cells. Fused to a His-tag.

Catalogus nummer: ENZOALX201285C002

UOM: 1 * 1 EA

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Omschrijving: Produced in <i>E. coli</i>.

Catalogus nummer: ENZOALX201057U100

UOM: 1 * 1 Flacon

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Omschrijving: Produced in <i>E. coli</i>.

Catalogus nummer: ENZOALX201047U100

UOM: 1 * 1 Flacon

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Omschrijving: Human cytotoxic granules of NK-92 cells.

Catalogus nummer: ENZOALX200605C010

UOM: 1 * 1 EA

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