Anti-CD45RO Mouse Monoclonal Antibody [clone: UCHL1] (APC)

Leverancier: STEMCELL Technologies
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60097AZ 60097AZ.1
STMC60097AZEA 441 EUR
STMC60097AZ STMC60097AZ.1
Anti-CD45RO Mouse Monoclonal Antibody [clone: UCHL1] (APC)
Antilichamen
Mouse monoclonal IgG2a antibody against human, chimpanzee, common marmoset CD45RO, APC-conjugated.

  • Leukocytes
  • T cells
  • T cells CD4
  • T cells CD8

The UCHL1 antibody reacts with an extracellular epitope on CD45RO, which is the shortest isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4, 5 and 6 that encode the extracellular RA, RB and RC polypeptides of CD45 gives rise to up to 8 isoforms with molecular masses of 180 - 240 kDa. Excision of all three exons generates the ~180 kDa CD45RO isoform, which is expressed on activated and memory (but not naïve) T cells, some B cell subsets, activated monocytes and macrophages, and granulocytes. CD45RO enhances both T cell receptor- and B cell receptor-mediated activation and is a known ligand for CD22 on B cells. The UCHL1 antibody has been used to identify T cell lymphomas and leukemia and is commonly used in combination with antibodies against CD45RA to discern memory and naïve T cells. The proportion of CD45RO+ (memory) T cells typically increases with age. The UCHL1 epitope is destroyed by treatment with neuraminidase or O-glycosidase.

Opgelet: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD45RO
Clonality: Monoclonal
Clone: UCHL1
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Chimpanzee, Common marmoset, Human
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