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Leverancier: STEMCELL Technologies

Omschrijving: Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (trkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew <i>et al.</i>). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera <i>et al.</i>). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan <i>et al.</i>). This product is animal component-free.

Leverancier: STEMCELL Technologies

Omschrijving: Epidermal growth factor (EGF) is characterized by high-affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright <i>et al.</i>). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss). This product is animal component-free.

Leverancier: STEMCELL Technologies

Omschrijving: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>). This product is animal component-free.

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic isolation of untouched human naïve pan T cells.

Leverancier: STEMCELL Technologies

Omschrijving: Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant <i>et al.</i>). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms <i>et al.</i>). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into T helper type 2 (Th2) cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao <i>et al.</i>; Olpihant <i>et al.</i>; Nelms <i>et al.</i>). In addition to Th2 T cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. IL-4 consists of 130 amino acids with a predicted molecular weight of 15.1 kDa. Human IL-4 does not cross-react with mouse cells (Park <i>et al.</i>). This product is animal component-free.

Catalogus nummer: (STMC01996)

Leverancier: STEMCELL Technologies

Omschrijving: For detection and measurement of mouse immunoglobulin A.

UOM: 1 * 1 Kit

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Catalogus nummer: (STMC04636)

Leverancier: STEMCELL Technologies

Omschrijving: Serum-free methylcellulose-based medium with recombinant cytokines for human ES and iPS cell-derived cells.

UOM: 1 * 100 mL

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Leverancier: STEMCELL Technologies

Omschrijving: Rat monoclonal IgG1, antibody against mouse IFN-gamma, APC-conjugated.

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic positive selection of human CD34+ cells from whole blood or buffy coat.

Catalogus nummer: (STMC09950)

Leverancier: STEMCELL Technologies

Omschrijving: Supplement for the differentiation of lymphoid progenitors to NK cells.

UOM: 1 * 0,5 mL

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Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic positive selection of human EpCAM+ cells (e.g. mammary epithelial cells).

Leverancier: STEMCELL Technologies

Omschrijving: DNase- and RNase-free water for molecular biology applications.

Leverancier: STEMCELL Technologies

Omschrijving: Amine-labelling fluorescent dye for live/dead staining of mammalian cells - 100 tests.

Catalogus nummer: (STMC10961)

Leverancier: STEMCELL Technologies

Omschrijving: Serum-free medium for differentiation of human monocytes to macrophages.

UOM: 1 * 250 mL

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Catalogus nummer: (STMC100-0945)

Leverancier: STEMCELL Technologies

Omschrijving: Serum-free methylcellulose-based medium with recombinant cytokines for human hematopoietic cells.

UOM: 1 * 100 mL

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Catalogus nummer: (STMC100-0995)

Leverancier: STEMCELL Technologies

Omschrijving: Fluorescent hydrophobic dye that selectively accumulates in mitochondria - 500 tests.

UOM: 1 * 500 ST

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