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Product Image-HT102A-1KT

Reticulum Stain Kit acc. to Gordon & Sweets, Sigma-Aldrich®

Catalogus nummer: (HT102A-1KT)
Leverancier: SIGMA ALDRICH MICROSCOPY
Omschrijving: The kit is based upon the method of Gordon and Sweets.
UOM: 1 * 1 Kit
Image Unavailable-BOSSBS-2358R-A750

Anti-FOXA2/HNF 3beta Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalogus nummer: (BOSSBS-2358R-A750)
Leverancier: Bioss
Omschrijving: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-ENZOBML28330100

Protease inhibitor library, Screen-Well®

Leverancier: ENZO LIFE SCIENCES
Omschrijving: The Screen-Well™ Protease Inhibitor Library includes 53 known protease inhibitors on a single 96-well plate. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 microliters per well. The library includes inhibitors to a broad range of important proteases and is a convenient and cost-effective way to purchase a panel of protease inhibitors for chemical genomics, assay development, and other applications. It includes inhibitors of: Calpains, TPPII, Neutrophil Elastase, Cathepsins, DPPIV, Caspases, Granzyme B, gamma-Secretase, Furin, MMPs, ACE, Kallikrein, Proteasome, Aminopeptidase B, and many more.

New Product

Image Unavailable-BOSSBS-2358R-A647

Anti-FOXA2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-2358R-A647)
Leverancier: Bioss
Omschrijving: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Product Image-1.50645.0001

UHPLC Purospher® STAR RP-18 endcapped kolommen

Leverancier: Merck
Omschrijving: Deze UHPLC-kolommen op basis van Purospher® STAR RP-18 endcapped zijn beschikbaar als geoptimaliseerde silicadeeltjes van 2 μm en ideaal voor ultrasnelle toepassingen, waarbij resolutie, gevoeligheid en monsterdoorvoer cruciaal zijn. Ze zijn de eerste keus voor screening met hoge doorvoer en QC-analyses, procesbewaking, methodeontwikkeling en LC/MS-toepassingen. Dankzij de uitgebalanceerde selectiviteit kunnen de Purospher® STAR RP-18 endcapped UHPLC-kolommen bijna alle veeleisende scheidingen met tailing-free chromatogrammen uitvoeren. De Purospher® STAR RP-18 endcapped 3 μm-kolommen worden aanbevolen voor moeilijke monsters waarbij verstopping en tegendruk een probleem vormen.

MSDS

Image Unavailable-MDT100-1KT

Tissue Marking Dye Kit, Sigma-Aldrich®

Catalogus nummer: (MDT100-1KT)
Leverancier: SIGMA ALDRICH MICROSCOPY
Omschrijving: Designed for orientation of excised surgical specimens. This method of permanently marking the margins of tissue specimens is very beneficial to surgeon and pathologists testing for skin cancer.
UOM: 1 * 1 Kit
Image Unavailable-BOSSBS-2358R-CY3

Anti-FOXA2 Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-2358R-CY3)
Leverancier: Bioss
Omschrijving: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2358R-A555

Anti-FOXA2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalogus nummer: (BOSSBS-2358R-A555)
Leverancier: Bioss
Omschrijving: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8634R-HRP

Anti-FOXA1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalogus nummer: (BOSSBS-8634R-HRP)
Leverancier: Bioss
Omschrijving: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
UOM: 1 * 100 µl
Image Unavailable-1.11148.0001

Visuele kleurenkits, sulfiettest, MColortest™, Supelco®

Catalogus nummer: (1.11148.0001)
Leverancier: Merck
Omschrijving: MQuant® titrimetric and colorimetric methods.
UOM: 1 * 1 EA

MSDS Certificaten


Image Unavailable-REST32542

EPA Method 525.3 OCP Cal Standard, 500 µg/ml, Acetone, 1 ml/Ampul

Catalogus nummer: (REST32542)
Leverancier: Restek
Omschrijving: Developed specifically for EPA Method 525.3.
UOM: 1 * 1 ST

New Product


Image Unavailable-1.10307.0500

Reagentiaset voor proteïne en vezel analyze, Supelco®

Catalogus nummer: (1.10307.0500)
Leverancier: Merck
Omschrijving: Testkit, Eiwit (Biuret-methode bij 546 nm), reagensoplossing voor ca. 250 tests
UOM: 1 * 500 mL

MSDS Certificaten


Image Unavailable-PROONIST-612

Glass - trace elements, NIST standards

Leverancier: LGC Standards PROMOCHEM
Omschrijving: This standard reference material is intended to facilitate the development of chemical methods of analysis for trace elements.

Product Image-ENZOENZ450140100

EpiXtract® total histone extraction kit

Catalogus nummer: (ENZOENZ450140100)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Rapid, reliable method to isolate histone proteins in mammalian cells and tissues for histone modification applications.
UOM: 1 * 1 Kit

New Product


Image Unavailable-A-057-1.2ML

Multi-component alcohol mixtures for calibration, Cerilliant®, Supelco®

Leverancier: Merck
Omschrijving: Multi-component calibration kits containing acetone, ethanol, isopropanol, and methanol varying concentrations. These kits ares suitable for calibration of blood alcohol testing methods using GC Headspace.

Image Unavailable-ENZOBMLKI1770005

Fluor-de-Lys® SIRT1 deacetylase substrate

Catalogus nummer: (ENZOBMLKI1770005)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Fluor de Lys®-SIRT1 is a fluorogenic, acetylated peptide substrate for SIRT1 (human Sirtuin 1). Based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases (lysines 381, 382), it was the best substrate for SIRT1 from among a panel of substrates patterned on p53, histone H3, and histone H4 acetylation sites. Fluor de Lys®-SIRT1 is deacetylated by SIRT1 (BML-SE239) at a rate of more then 8-fold that of the acetylated lysine substrate, Fluor de Lys® (Prod. No. BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+). The Km of Fluor de Lys®-SIRT1 for human recombinant Sirtuin 1 is 108 µM (determined at 37°C, 500 µM NAD+). Must be used in conjunction with Fluor de Lys® Developer II (Prod. No. BML-KI176). Fluorescent signal indicates deacetylation of Lys382. Sufficient for 100-200 assays of human recombinant SIRT1 (1U/well, 50-100 µM substrate).
UOM: 1 * 1 Flacon

New Product


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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