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Image Unavailable-BOSSBS-5708R-A350

Anti-SUV39H1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-5708R-A350)
Leverancier: Bioss
Omschrijving: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.
UOM: 1 * 100 µl
Product Image-HICH99309

Avantor® Prevail C18-Select, HPLC Columns

Leverancier: Avantor
Omschrijving: Prevail™ HPLC columns exhibit long column lifetime in both highly aqueous and highly organic mobile phases. All phases, apart from Prevail™ Carbohydrate ES are silica-based. The stability of these phases is such that a single column can be switched between highly aqueous for analysis of highly polar analytes and highly organic for strong retention of hydrophobic analytes.

Image Unavailable-BOSSBS-1286R-CY3

Anti-CD40L Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-1286R-CY3)
Leverancier: Bioss
Omschrijving: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD4L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13282R-CY3

Anti-GAPDHS Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-13282R-CY3)
Leverancier: Bioss
Omschrijving: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
UOM: 1 * 100 µl
Product Image-BRDY090892

Breaker lockout kit

Leverancier: Brady
Omschrijving: These breaker blockers are ideal for locking out oversized and irregularly shaped switches.

Product Image-118-0518

Mini-kabelvergrendelingssystemen

Leverancier: Brady
Omschrijving: Deze mini-kabelvergrendelingen zijn perfect voor gebruik op ontkoppelingsschakelaars, kleine schuifafsluiters en meer.

Image Unavailable-BOSSBS-6010R

Anti-GTPBP4 Rabbit Polyclonal Antibody

Catalogus nummer: (BOSSBS-6010R)
Leverancier: Bioss
Omschrijving: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [Entrez Gene]
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9526R-A488

Anti-KLF1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalogus nummer: (BOSSBS-9526R-A488)
Leverancier: Bioss
Omschrijving: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5370R-A680

Anti-GATA1 Ser310 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-5370R-A680)
Leverancier: Bioss
Omschrijving: GATA1 is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch from foetal hemoglobin production to adult hemoglobin.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5370R-A647

Anti-GATA1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-5370R-A647)
Leverancier: Bioss
Omschrijving: GATA1 is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch from fetal hemoglobin production to adult hemoglobin.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12520R-A647

Anti-ARID1B Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-12520R-A647)
Leverancier: Bioss
Omschrijving: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9526R-CY3

Anti-KLF1 Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-9526R-CY3)
Leverancier: Bioss
Omschrijving: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9526R-CY7

Anti-KLF1 Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-9526R-CY7)
Leverancier: Bioss
Omschrijving: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
UOM: 1 * 100 µl
Product Image-HICH88665

Avantor® Prevail Amide, HPLC Columns

Leverancier: Avantor
Omschrijving: Prevail™ HPLC columns exhibit long column lifetime in both highly aqueous and highly organic mobile phases. All phases, apart from Prevail™ Carbohydrate ES, are silica-based. The stability of these phases is such that a single column can be switched between highly aqueous for analysis of highly polar analytes and highly organic for strong retention of hydrophobic analytes.

Image Unavailable-BOSSBS-5330R-CY7

Anti-RHOA Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-5330R-CY7)
Leverancier: Bioss
Omschrijving: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5330R-A647

Anti-RHOA Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-5330R-A647)
Leverancier: Bioss
Omschrijving: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
UOM: 1 * 100 µl
Bel voor prijs
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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