U heeft gezocht op: Fluorescein-dT+CPG

Catalogus nummer: (BOSSBS-5915R-FITC)

Leverancier: Bioss

Omschrijving: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-8335R-FITC)

Leverancier: Bioss

Omschrijving: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-9721R-FITC)

Leverancier: Bioss

Omschrijving: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

UOM: 1 * 100 µl

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Leverancier: AAT BIOQUEST

Omschrijving: There are several ways of labeling an oligonucleotide with fluorescein. The choice of label is diversified further, depending on the spectral requirements. 5'-fluorescein-CE phosphoramidite, derived from the single isomer 6-carboxyfluorescein, 5'-hexachlorofluorescein-CE phosphoramidite (HEX) and 5'-tetrachlorofluorescein-CE phosphoramidite (TET) can all be used to efficiently label an oligonucleotide at the 5'-end. Labeling the 3'-end of an oligo with fluorescein can be achieved using 3'-Fluorescein CPGs. Standard cleavage and deprotection with ammonium hydroxide liberates the fluorescein-labeled oligo when using any of these supports.

Catalogus nummer: (APOSBIMN2047-250MG)

Leverancier: Apollo Scientific

Omschrijving: 6-SIMA-dT phosphoramidite

UOM: 1 * 250 mg

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Catalogus nummer: (MMMADT-1135E)

Leverancier: 3M

Omschrijving: For effective protection against a range of particulates, gases and vapours or combination hazards, use 3M™ filters DT-Series. Suitable for use with certain 3M™ half and full-face tight-fitting respirators in negative-pressure mode as well as 3M™ powered air respirator system PF-600E+ series.

UOM: 1 * 10 ST

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Leverancier: VWR Chemicals

Omschrijving: Gebruiksklare dNTP-mengsels en dNTP-sets van moleculair-biologische kwaliteit. Het dNTP-mengsel is ontwikkeld om de onderzoekers tijd te besparen en de kans op besmetting te reduceren doordat er minder pipetteerhandelingen nodig zijn. De dNTP-oplossingen zijn tevens verkrijgbaar in sets met vier afzonderlijke dNTP's van elk 100 mM. Beide uitvoeringen zijn handig voor gebruik bij PCR-reacties, DNA-labeling en sequencing reacties.

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Leverancier: 3M

Omschrijving: 3M™ reusable full face mask, FF-600 series features a panoramic visor that allows for a virtually unrestricted field of vision. Compatible with the 3M™ filters, DT series, the FF-600 series is suitable for a wide range of wearers and applications.

Catalogus nummer: (MMMA7100260622)

Leverancier: 3M

Omschrijving: For effective protection against a range of particulates, gases, and vapours, or combination hazards, use 3M™ filters DT series. Suitable for use with certain 3M™ half and full-face tight-fitting respirators in negative-pressure mode as well as 3M™ powered air respirator system PF-600E+ series.

UOM: 1 * 10 ST

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Catalogus nummer: (APOSBIT2044-25G)

Leverancier: Apollo Scientific

Omschrijving: Thymidine (2'-deoxythymidine)

UOM: 1 * 25 g

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Leverancier: Thermo Fisher Scientific

Omschrijving: Thymidine (2'-deoxythymidine) 99+%

MSDS

Leverancier: 3M

Omschrijving: 3M™ Full Facepiece Reusable Respirator is multi-function full-face mask designed to provide durable and comfortable protection against a wide range of respiratory hazards. Use in conjunction with approved 3M powered air systems or as a negative pressure respirator with the 3M™ DT Series filter range, providing protection against a wide range of industrial hazards.

Leverancier: 3M

Omschrijving: The 3M™ full facepiece reusable respirator FF-600 series can be used with approved 3M™ DT-Series filters with a 40 mm (EN 148-1) thread, or they can be used as part of an approved powered air respirator system using the appropriate breathing tube. Both combinations protect against gases, vapours and/or particulates depending on your individual needs.

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Leverancier: Thermo Fisher Scientific

Omschrijving: Thymidine (2'-deoxythymidine) ≥99%

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Catalogus nummer: (BOSSBS-5714R)

Leverancier: Bioss

Omschrijving: OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.

UOM: 1 * 100 µl

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Leverancier: AAT BIOQUEST

Omschrijving: Alkynyl-dT-Phosphoramidite is an excellent building block for introducing an alkyne group into an oligo via dT.

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