U heeft gezocht op: LY-2157299

Catalogus nummer: (BOSSBS-6478R-CY7)

Leverancier: Bioss

Omschrijving: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

UOM: 1 * 100 µl

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Leverancier: Apollo Scientific

Omschrijving: Specific inhibitor (IC50 = 1.40 uM) of phosphatidylinositol 3-kinase (PI3K).

Catalogus nummer: (BOSSBS-11921R-HRP)

Leverancier: Bioss

Omschrijving: Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me).

UOM: 1 * 100 µl

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Catalogus nummer: (ACRO365650250)

Leverancier: Thermo Fisher Scientific

Omschrijving: DL-Lysine monohydrate 97%

UOM: 1 * 25 g

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Catalogus nummer: (BOSSBS-7735R-A680)

Leverancier: Bioss

Omschrijving: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonising the inhibitory action of SMAD6 and SMAD7.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-6921R-CY5.5)

Leverancier: Bioss

Omschrijving: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-3051R-A555)

Leverancier: Bioss

Omschrijving: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-11921R-A488)

Leverancier: Bioss

Omschrijving: Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me).

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-11921R-FITC)

Leverancier: Bioss

Omschrijving: Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me).

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-6478R-CY5.5)

Leverancier: Bioss

Omschrijving: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

UOM: 1 * 100 µl

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Catalogus nummer: (APOSOR54645-100G)

Leverancier: Apollo Scientific

Omschrijving: (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid 98%

UOM: 1 * 100 g

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Leverancier: TCI

Omschrijving: Nε-carbobenzoxy-Nɑ-tosyl-L-lysine ≥98.0% (by HPLC)

Catalogus nummer: (BOSSBS-8389R-A350)

Leverancier: Bioss

Omschrijving: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-8389R-FITC)

Leverancier: Bioss

Omschrijving: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-11866R-CY3)

Leverancier: Bioss

Omschrijving: Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).

UOM: 1 * 100 µl

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Catalogus nummer: (BOSSBS-1865R-A555)

Leverancier: Bioss

Omschrijving: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM2, USP3, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1 and USP3 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

UOM: 1 * 100 µl

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