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Image Unavailable-PRSI92-128

Human recombinant Cytochrome C (from E. coli)

Catalogus nummer: (PRSI92-128)
Leverancier: ProSci Inc.
Omschrijving: Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of Cytochrome C to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
UOM: 1 * 1 EA
Image Unavailable-APOSBII0421-10MG

Ionomycin free acid

Leverancier: Apollo Scientific
Omschrijving: Potent and selective calcium ionophore.

Image Unavailable-APOSOR18345-100G

2-Aminobenzothiazole 97%

Leverancier: Apollo Scientific
Omschrijving: 2-Aminobenzothiazole 97%

Image Unavailable-ENZOALX350233M001

Gramicidin A (from Bacillus brevis) ≥90% (by HPLC)

Leverancier: ENZO LIFE SCIENCES
Omschrijving: Ionophore antibiotic.

Image Unavailable-A13521.22

2-Aminobenzothiazole 98%

Leverancier: Thermo Fisher Scientific
Omschrijving: 2-Aminobenzothiazole 98%

MSDS Certificaten

Image Unavailable-ENZOBMLCA1000010

Calcimycin (A23187) (from Streptomyces chartreusis) ≥99% (by TLC)

Catalogus nummer: (ENZOBMLCA1000010)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Antibiotic possessing weak<i> in vitro</i> antimicrobial activity against gram positive bacteria and fungi. A highly selective divalent cation ionophore, commonly used to increase intracellular Ca<sup>2⁺</sup> levels in intact cells.
UOM: 1 * 10 mg
Image Unavailable-ENZOADISPA224F

Anti-CRYAA Rabbit Polyclonal Antibody

Leverancier: ENZO LIFE SCIENCES
Omschrijving: Alpha-crystallins composed of alpha A (~20 kDa) and alpha B (~20 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. The two other crystallin families, beta and gamma, are homologous to each other but not to the alpha family or the sHsp's. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The alpha-crystallins have sequence homology as well as structural and functional similarities with the small Hsp's such as Hsp25/27. Most small heat shock proteins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of alphaA-crystallin, alphaB-crystallin and Hsp25/27; (iii) the moderately conserved alpha-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The alpha-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation, although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease.

Product Image-ACRO385120500

Valinomycin 98%

Leverancier: Thermo Fisher Scientific
Omschrijving: Valinomycin 98%

MSDS

Image Unavailable-BOSSBS-1607R-HRP

Anti-CK 2 alpha Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Catalogus nummer: (BOSSBS-1607R-HRP)
Leverancier: Bioss
Omschrijving: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation.
UOM: 1 * 100 µl
Image Unavailable-TCIAA0277-500G

2-Aminobenzothiazole ≥97.0% (by HPLC, titration analysis)

Leverancier: TCI
Omschrijving: 2-Aminobenzothiazole ≥97.0% (by HPLC, titration analysis)

Product Image-ACRO148810050

2-Aminobenzothiazole 97%

Leverancier: Thermo Fisher Scientific
Omschrijving: 2-Aminobenzothiazole 97%

MSDS

Image Unavailable-TCIAD2321-5G

N,N'-Dibenzyl-4,13-diaza-18-crown 6-ether ≥98.0% (by GC, titration analysis)

Leverancier: TCI
Omschrijving: N,N'-Dibenzyl-4,13-diaza-18-crown 6-ether ≥98.0% (by GC, titration analysis)

Image Unavailable-59006.

4-Bromo-A-23187 free acid ≥98% (by TLC, NMR) ionophore, for calcium determination

Catalogus nummer: (59006.)
Leverancier: Biotium
Omschrijving: Similar to A-23187, 4-Bromo A-23187 is used for in situ calibrations of fluorescent Ca2 indicators to equilibrate intracellular and extracellular calcium concentrations and to allow Mn2 to enter cells to quench indicator fluorescence. However, since 4-bromo A-23187 is nonfluorescent, it is preferred over the blue fluorescent A-23187 for calibrations of UV-excited Ca2 indicators such as Indo-1 and Fura-2 in order to keep background fluorescence to a minimum.
UOM: 1 * 1 mg
Image Unavailable-ENZOALX385016G001

Morin ≥85%

Catalogus nummer: (ENZOALX385016G001)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Cell cycle inhibitor
UOM: 1 * 1 g
Image Unavailable-ENZOALX450008M025

Nonactin (from Streptomyces griseus) ≥98% (by TLC)

Leverancier: ENZO LIFE SCIENCES
Omschrijving: Macrotetrolide antibiotic. Monovalent cation ionophore with high selectivity for ammonium and potassium. Specifically inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria. Inhibits the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in multidrug resistant (MDR) cancer cells.

Product Image-PRSI4359

Anti-TEM1 Rabbit Polyclonal Antibody

Catalogus nummer: (PRSI4359)
Leverancier: ProSci Inc.
Omschrijving: TEM1 Antibody: Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion.
UOM: 1 * 1 EA
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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