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Product Image-568-2169

Capillary columns, Rtx®-624

Leverancier: Restek
Omschrijving: Application-specific columns for volatile organic pollutants. Recommended in U.S. EPA methods for volatile organic pollutants.

Product Image-390-0763

Gekoelde incubatoren, CTX series

Leverancier: CLIMATRONIX
Omschrijving: De CTX-GI–serie is speciaal ontwikkeld voor langdurig bewaren (long term), ICH stabiliteitsstudies waarbij men medicijnen moet bewaren bij lage temperaturen. Deze temperaturen zijn bepaald door FDA-ICH en omvatten +5 °C en -20 °C. Dankzij de PID-controller, die gekenmerkt staat als een gebruiksvriendelijke regelaar en eenvoudige programmering, kunnen alle gewenste programma's uitgevoerd worden. Er werd bijzondere aandacht besteed aan de automatische ontdooiing opdat tijdens deze fase de testgoederen niet buiten hun werktoleranties zouden komen. Dankzij de performante compressor met milieuvriendelijk koelmiddel, R134a of R404a, kan er snel gekoeld worden. Het verwarmingselement ingebouwd in de verdamper zorgt voor het opwarmen van de testruimte. Mobiele uitvoering is vier zwenkwielen waarvan twee met rem voor model CTX-GI-700 en vijf zwenkwielen waarvan twee met rem voor model CTX-GI-1400.

Product Image-216-6903

Aluminium inserts for ice baths

Leverancier: KOEHLER TECHNISCHE PRODUKTEN
Omschrijving: The inserts are simply mounted in the special groove.

Image Unavailable-H66315.MC

BTP-4Cl, Organic Photovoltaics (OPV) reagent

Leverancier: Thermo Fisher Scientific
Omschrijving: BTP-4Cl, Organic Photovoltaics (OPV) reagent

Product Image-ABCAAB259761-1

Anti-BTC Rabbit Monoclonal Antibody [clone: EPR22344-85]

Leverancier: Abcam
Omschrijving: Rabbit monoclonal [EPR22344-85] to BTC - BSA and Azide free (Capture).

Image Unavailable-BOSSBS-11813R-CY5

Anti-BTD Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-11813R-CY5)
Leverancier: Bioss
Omschrijving: Biotin, also known as vitamin B7, is an essential water-soluble vitamin that is a cofactor in glucogenesis and in the metabolism of fatty acids and leucine. Biotinidase is a 523 amino acid enzyme that catalyzes the hydrolysis of biocytin to biotin and lysine. Secreted into extracellular space, biotinidase is expressed in liver, heart, placenta, brain, skeletal muscle, pancreas and kidney. Biotinidase contains one carbon-nitrogen hydrolase domain, which is involved in the reduction of organic nitrogen compounds and ammonia production. Defects in the gene encoding biotinidase are the cause of biotinidase deficiency, which is characterized by skin rash, ataxia, seizures, hearing loss, hypotonia and optic atrophy. These symptoms are due to the individual’s inability to reutilize biotin and can, therefore, typically be treated with the addition of free biotin.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2752R-CY7

Anti-BTK Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-2752R-CY7)
Leverancier: Bioss
Omschrijving: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0127R-CY7

Anti-BAX Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-0127R-CY7)
Leverancier: Bioss
Omschrijving: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
UOM: 1 * 100 µl
Product Image-ABCAAB245009-100

Anti-Bax Rabbit Monoclonal Antibody [clone: E63]

Leverancier: Abcam
Omschrijving: Rabbit monoclonal [E63] to Bax - BSA and Azide free (Detector).

Image Unavailable-ENTESB300-EN8-52

Full Pitch Front Opening Shipping Boxes (FOSBs), SB300

Catalogus nummer: (ENTESB300-EN8-52)
Leverancier: ENTEGRIS
Omschrijving: Automated, FIMS compatible SB300 FOSB provides a clean, secure environment for valuable 300 mm wafers as they move through numerous handling and transport processes.
UOM: 1 * 2 ST

New Product


Image Unavailable-BOSSBS-3069R-CY7

Anti-BTK Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-3069R-CY7)
Leverancier: Bioss
Omschrijving: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3069R-CY5

Anti-BTK Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-3069R-CY5)
Leverancier: Bioss
Omschrijving: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
UOM: 1 * 100 µl
Product Image-ABCAAB314315-20UL

Anti-ENPP2/ATX Rabbit Monoclonal Antibody [clone: EPR27348-30]

Leverancier: Abcam
Omschrijving: Rabbit monoclonal [EPR27348-30] to ENPP2/ATX.

New Product

Product Image-ABCAAB300513-20UL

Anti-KDM6A / UTX Rabbit Monoclonal Antibody [clone: EPR26387-23]

Leverancier: Abcam
Omschrijving: Rabbit monoclonal [EPR26387-23] to KDM6A / UTX.

New Product

Product Image-ABCAAB36938-100

Anti-KDM6A / UTX Rabbit Polyclonal Antibody

Catalogus nummer: (ABCAAB36938-100)
Leverancier: Abcam
Omschrijving: Rabbit polyclonal to KDM6A / UTX.
UOM: 1 * 1 EA
Product Image-BOHLV1847-06

Mini desiccator, SICCO Mini Secure Box

Leverancier: Bohlender
Omschrijving: Clear polycarbonate lockable desiccators with single door with snap fit closing and integrated gasket ensuring easy opening and tight closure. Temperature resistant from −35 to +70 °C, suitable for use under normal pressure.

Bel voor prijs
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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