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Image Unavailable-BOSSBS-7416R-A350

Anti-POLD2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-7416R-A350)
Leverancier: Bioss
Omschrijving: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).
UOM: 1 * 100 µl
Image Unavailable-BWRLBS1091

Anti-DNA pol beta Rabbit Polyclonal Antibody [clone: Q324]

Catalogus nummer: (BWRLBS1091)
Leverancier: Bioworld Technology
Omschrijving: Synthetic peptide, corresponding to amino acids 301-350 of Human DNA pol beta.
UOM: 1 * 1 EA
Image Unavailable-BOSSBS-13021R-A750

Anti-DNA polymerase mu Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalogus nummer: (BOSSBS-13021R-A750)
Leverancier: Bioss
Omschrijving: DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13021R-A680

Anti-DNA polymerase mu Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-13021R-A680)
Leverancier: Bioss
Omschrijving: DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13018R-A680

Anti-DNA Polymerase iota Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-13018R-A680)
Leverancier: Bioss
Omschrijving: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol , which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
UOM: 1 * 100 µl
Image Unavailable-ECHLJMAG0209

Objectives for REVOLVE 3M microscope

Leverancier: DISCOVER ECHO
Omschrijving: Plan fluorite pol; 0,13 NA, Revolve, 4×, Werkafstand: 17 mm

Image Unavailable-BOSSBS-13021R-HRP

Anti-POLM Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalogus nummer: (BOSSBS-13021R-HRP)
Leverancier: Bioss
Omschrijving: DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
UOM: 1 * 100 µl
Product Image-663-0375

Multiparameter photometer, Water-ID® The PrimeLab 2.0

Catalogus nummer: (663-0375)
Leverancier: WATER ID PRIMELAB
Omschrijving: The next generation of multitest Photometer, with pH - EC - TDS - ORP - Temperature measurement functionality.
UOM: 1 * 1 ST
Image Unavailable-BOSSBS-13021R-CY5

Anti-POLM Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-13021R-CY5)
Leverancier: Bioss
Omschrijving: DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13021R-CY3

Anti-POLM Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-13021R-CY3)
Leverancier: Bioss
Omschrijving: DNA polymerase mu shares a number of characteristics with DNA polymerase Beta as well as with terminal deoxynucleotideyltransferase. Pol mu purportedly plays a role in microhomology mediated joining and the repair of double-stranded breaks. However, unlike other DNA polymerases, which show substrate specificity for deoxynucleotides, DNA Pol mu incorporates both deoxynucleotides and ribonucleotides in a template- directed manner. This unusual capability implies a novel role for this polymerase in DNA repair.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13020R-CY5

Anti-POLK Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-13020R-CY5)
Leverancier: Bioss
Omschrijving: DNA polymerase lambda (pol lambda), also designated DNA polymerase lambda or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol lambda is a member of the DNA polymerase type-X family. Pol lambda extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ?may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol lambda and thus influences the ability of pol ?to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13020R-CY7

Anti-POLK Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-13020R-CY7)
Leverancier: Bioss
Omschrijving: DNA polymerase lambda (pol lambda), also designated DNA polymerase lambda or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol lambda is a member of the DNA polymerase type-X family. Pol lambda extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ?may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol lambda and thus influences the ability of pol ?to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13019R-A488

Anti-POLK Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalogus nummer: (BOSSBS-13019R-A488)
Leverancier: Bioss
Omschrijving: DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13019R-CY5

Anti-POLK Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-13019R-CY5)
Leverancier: Bioss
Omschrijving: DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6582R-A750

Anti-RNA polymerase 2 CTD repeat YSPTSPS phospho Ser5 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalogus nummer: (BOSSBS-6582R-A750)
Leverancier: Bioss
Omschrijving: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesises mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6582R-A680

Anti-RNA polymerase 2 CTD repeat YSPTSPS phospho Ser5 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-6582R-A680)
Leverancier: Bioss
Omschrijving: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesises mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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