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Image Unavailable-BOSSBS-0439R-A680

Anti-ACE Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-0439R-A680)
Leverancier: Bioss
Omschrijving: Angiotensin Converting enzyme is involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2988R-A680

Anti-Mitofusin 2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-2988R-A680)
Leverancier: Bioss
Omschrijving: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11349R-CY3

Anti-ICA1 Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-11349R-CY3)
Leverancier: Bioss
Omschrijving: Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the ?carbonic anhydrase family encode either active carbonic anhydrase isozymes or 揳catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11349R-A350

Anti-ICA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-11349R-A350)
Leverancier: Bioss
Omschrijving: Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the ?carbonic anhydrase family encode either active carbonic anhydrase isozymes or 揳catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12335R-CY5

Anti-HFE Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-12335R-CY5)
Leverancier: Bioss
Omschrijving: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
UOM: 1 * 100 µl
Product Image-REST31223

Calibration mix D3710-95 (16 components)

Catalogus nummer: (REST31223)
Leverancier: Restek
Omschrijving: These calibration mixtures are made with pure, highly characterized neat material and are prepared using NIST-traceable balances and weights. Each ampul is supplied with a data sheet indicating the exact concentration and a sample chromatogram.
UOM: 1 * 1 ST
Image Unavailable-BOSSBS-12938R

Anti-CSGALNACT1 Rabbit Polyclonal Antibody

Catalogus nummer: (BOSSBS-12938R)
Leverancier: Bioss
Omschrijving: The chondroitin N-acetylgalactosaminyltransferase family includes Beta-1,4-GalNAc-T, Beta-1,4-GalNAc-T2, Beta-1,4-GalNAc-T3 and Beta-1,4-GalNAc-T4. The Beta-1,4-GalNAc-T protein consists of a short N-terminal residue, a transmembrane region and a long C-terminal residue, which includes a catalytic domain and localizes to the Golgi apparatus. Beta-1,4-GalNAc-T utilizes simple ganglioside GM3 as a substrate for more complex gangliosides GM2, GM1 and GD1a. Beta-1,4-GalNAc-T is expressed in normal brain tissues and in various malignant transformed cells, such as malignant melanoma, neuroblastoma and adult T cell leukemia. Mice lacking the Beta-1,4-GalNAc-T protein develop significant and progressive behavioral neuropathies, including deficits in reflexes, strength, coordination and balance. Beta-1,4-GalNAc-T is a potential molecular marker for detecting melanoma cells and monitoring tumor progression.
UOM: 1 * 100 µl
Product Image-SART17845-R

Spuitfilters, Minisart® NY

Leverancier: Sartorius
Omschrijving: Minisart® NY with hydrophilic polyamide (nylon) is optimised for aqueous liquids and solvents with a pH of 3 to 14. Type 17845 with a pore size of 0,2 µm can be used for sample preparation and sterile filtration. It has a male Luer slip outlet and version ACK is individually packed and sterilised by ethylene oxide (EO).

Certificaten

Product Image-40-1243-U500

Anti-CD274 Rat Monoclonal Antibody [clone: 10F.9G2]

Leverancier: Tonbo Biosciences
Omschrijving: The 10F.9G2 antibody is specific for mouse CD274, more commonly known as PD-L1 or B7-H1, which acts as a ligand for the T cell co-regulatory receptor PD-1 (CD279). This interaction modulates T cell antigen receptor (TCR) signaling and therefore T cell activation. PD-L1 binding to PD-1 expressed on CD4- CD8- thymocytes participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-L1 may also bind PD-1 following the receptor’s inducible expression on activated, mature T cells, where it has been proposed to limit T cell activation. PD-L1 is one of a group of “B7” ligands whose interactions with the CD28 receptor family, also including CTLA-4 (CD152), provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

Image Unavailable-BOSSBS-11283R

Anti-FABP3 Rabbit Polyclonal Antibody

Catalogus nummer: (BOSSBS-11283R)
Leverancier: Bioss
Omschrijving: Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epidermis (E-FABP, also designated psoriasis-associated FABP or PA-FABP), muscle and heart (H-FABP, also designated mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP), myelin (M-FABP) and testis (T-FABP). MDGI is highly expressed in the myocardium, skeletal and smooth muscle fibers, lipid and/or steroid synthesizing cells and terminally differentiated epithelia of the respiratory, intestinal and urogenital tracts.
UOM: 1 * 100 µl
Product Image-101000005.

jetMESSENGER® mRNA Transfection Reagents

Leverancier: SARTORIUS
Omschrijving: jetMESSENGER® is een mRNA-transfectiereagens dat speciaal ontworpen werd om uitstekende transfectie-efficiëntie te bieden in cellen die normaal moeilijk te transfecteren zijn, hierdoor zijn relevante experimenten voor genexpressie in alle celtypen mogelijk.

New Product

Product Image-613-5492

Pipette stand, rotary

Catalogus nummer: (613-5492)
Leverancier: Sartorius
Omschrijving: Carousel stand for six mechanical pipettes.
UOM: 1 * 1 ST

Environmentally Preferable


Product Image-611-4978

Industriële weegschalen, Explorer® -serie

Leverancier: OHAUS
Omschrijving: Grote platformweegschaal met touchscreen, geavanceerde weeg- en nabijheidssensortechnologieën. De gebruiksvriendelijke bedieningseenheid kan op de basis worden gemonteerd, boven de basis op een optionele kolom, aan een muur of op afstand (tot 3 meter afstand met een optionele kabel). Het touchscreen-display met universele pictogrammen en informatieve aanwijzingen vereenvoudigt de instelfuncties en de basisbediening. De operator heeft de extra keuze om de nabijheidssensoren te gebruiken voor handsfree bediening voor het hanteren van gevoelige monsters. De weegschalen hebben meerdere toepassingsmodi voor basiswegen tot SQC-toepassingen, samen met korte stabilisatietijden en geoptimaliseerde prestatiespecificaties.

Product Image-SARTFT-3-305-110

Qualitative filter papers, technical, smooth, grade 3 m/N

Leverancier: Sartorius
Omschrijving: These smooth filter papers are made of refined pulp and linters with more than 95% alpha-cellulose content. The ash content of these filter papers is between 0,1 and 0,15%. They are used for routine analyses like clarification, determination of substances, but also as discs with a centre hole for technical applications. Grades with a wet burst resistance >30 kPa are referred to as wet-strengthened and are therefore suitable for pressure or vacuum filtration.

Product Image-611-5848

Moisture Analyser, MB32

Catalogus nummer: (611-5848)
Leverancier: OHAUS
Omschrijving: Perfect for routine moisture testing.
UOM: 1 * 1 ST

New Product


Product Image-135-1089

Accessories for glove boxes, HEPA filtered, Precise™ and weigh boxes, XPert™

Catalogus nummer: (135-1089)
Leverancier: LABCONCO
Omschrijving: Blower foot switch, incl. foot pedal and power cord; provides a hands-free means to temporarily shut off power when obtaining sensitive balance readings or manipulating fine powders
UOM: 1 * 1 ST
Bel voor prijs
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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