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Catalogus nummer: (ENZOALX350350M025)

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Omschrijving: iNOS inhibitor

UOM: 1 * 25 mg

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Catalogus nummer: (ENZOALX350362M025)

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Omschrijving: First phthalideisoquinoline hemiacetal from a natural source. Inhibits Ca²⁺ currents and contractile responses in vitro.

UOM: 1 * 25 mg

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Catalogus nummer: (ENZOALX350404M050)

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Omschrijving: Hydroxytyrosol acetate is an antioxidant comparable to resveratrol. It is converted to hydroxytyrosol through hydrolysis by esterases.

UOM: 1 * 50 mg

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Catalogus nummer: (ENZOADI905744100)

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Omschrijving: The opioid receptors δ, κ, and μ are members of the seven-transmembrane domain-containing receptor family of G-protein coupled receptors. δ- and μ-receptors serve as functional receptors for endogenous enkephalin and β-endorphin peptide ligands, respectively. δ-opioid receptors are highly expressed in the olfactory bulb, neocortex, caudate putamen and nucleus accumbens, with peripheral expression in the gastro-intestinal tract and vas deferens. δ-receptors inhibit neurotransmitter release resulting in a variety of biological effects including analgesia, motor integration, gastro-intestinal motility, olfaction, respiration, and memory. Neural μ-receptor expression is prominent in the caudate putamen, neocortex, thalamus, nucleus accumbens, hippocampus, and amygdala, as well as in peripheral nervous tissues in the gut. Named for its pharmacological mediation of analgesia by morphine, the μ receptor typically functions as a depressant in physiological processes including respiration, cardiovascular function, gastrointestinal motility, and thermoregulation.

UOM: 1 * 1 EA

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Catalogus nummer: (ENZOADI905750100)

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Omschrijving: Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.

UOM: 1 * 1 EA

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Catalogus nummer: (ENZOADI905721100)

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Omschrijving: Beclin-1 is a coiled-coil Bcl-2-interacting protein that functions in autophagy, the process of bulk degradation of cellular proteins. Beclin-1 is homologous to the yeast autophagy gene apg6, and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as both an anti-autophagic and anti-apoptotic protein.

UOM: 1 * 1 EA

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Catalogus nummer: (ENZOADI905743100)

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Omschrijving: The actions of the octapeptide circulatory hormone angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane domain-containing GPCR family. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II in cardiovascular homeostasis. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing.

UOM: 1 * 1 EA

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Catalogus nummer: (ENZOADI905741100)

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Omschrijving: Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine found in the central nervous system, gastrointestinal tract, and blood with broad physiological functions as a neurotransmitter, in gastric motility, hemostasis, and cardiovascular integrity. Seven subclasses (5-HT 1-7) of serotonin receptors have been identified, a majority of which are members of the seven transmembrane domain-containing G-protein coupled receptor (GPCR) family, and are the target of several anti-depressant drugs. The 5-HT1 subclass consists of five highly homologous receptors that couple via G(i/o) alpha subunits to inhibit adenylyl cyclase activity. The 5-HT1A receptor gene is 99% homologous between human and mouse, and is expressed from an intronless gene with a predicted length of 421 amino acids. 5-HT1A receptor activation is generally inhibitory to cAMP production, but may also stimulate type II adenylyl cyclase activity in a cell-specific manner via release of G(beta/gamma) subunits when coupled to G(i2). 5-HT1A expression in mammals is strongest in CNS limbic pathways that control emotion, including tissue of the hippocampus, dorsal raphé, and septum.

UOM: 1 * 1 EA

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Catalogus nummer: (ENZOADI905791100)

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Omschrijving: Endothelins are vasoactive peptides that exist in three forms (ET-1, ET-2, and ET-3), and function in the maintenance of vascular tone via two identified seven transmembrane-spanning domain-containing G protein-coupled receptors (GPCR), endothelin A (ETA) and endothelin B (ETB). The human ETA receptor is primarily expressed in vascular smooth muscle cells, including those of the heart (also in myocytes), lung, and brain, and its stimulation generally results in vasoconstriction. Activation of ETA receptors can be stimulated by binding of ET-1 and ET-2, but not ET-3. triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Human ETB receptors are primarily expressed in endothelial cells lining the vessel walls of the lungs, heart, and brain, and in contrast to ETA receptors, stimulation generally results in transient vasodilation. Activation of ETB receptors can be stimulated by binding of all three endothelins, triggering the release of vasorelaxive

UOM: 1 * 1 EA

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Omschrijving: Adenosine 5'-diphosphate disodium salt (ADP disodium salt)

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Catalogus nummer: (ENZOALX460036M001)

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Omschrijving: Vitamin D3 precursor

UOM: 1 * 1 mg

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Omschrijving: ß-Nicotinamide adenine dinucleotide phosphate (NADP-Na₂, oxidized form)

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Catalogus nummer: (ENZOALX440008M100)

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Omschrijving: L-Biopterin ≥98%

UOM: 1 * 100 mg

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Catalogus nummer: (ENZOALX480019M010)

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Omschrijving: DNA alkyltransferase substrate and inhibitor

UOM: 1 * 10 mg

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Catalogus nummer: (ENZOALX270097M025)

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Omschrijving: Ebselen

UOM: 1 * 25 mg

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Catalogus nummer: (ENZOALX270240M005)

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Omschrijving: CB1 receptor ligand.

UOM: 1 * 5 mg

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