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Image Unavailable-BOSSBS-13164R-A350

Anti-FLNA Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalogus nummer: (BOSSBS-13164R-A350)
Leverancier: Bioss
Omschrijving: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
UOM: 1 * 100 µl
Product Image-METOHP52K3

Dunnage rack, heavy-duty

Catalogus nummer: (METOHP52K3)
Leverancier: Metro International
Omschrijving: These heavy duty tubular construction is designed to withstand impact and hold heavy loads.
UOM: 1 * 1 ST
Image Unavailable-BOSSBS-2686R-A647

Anti-DKK3 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-2686R-A647)
Leverancier: Bioss
Omschrijving: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2162R-A647

Anti-DKK1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-2162R-A647)
Leverancier: Bioss
Omschrijving: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2686R-CY3

Anti-DKK3 Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-2686R-CY3)
Leverancier: Bioss
Omschrijving: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
UOM: 1 * 100 µl
Image Unavailable-ENZOBMLEI2280010

AG-494 ≥98% (by TLC)

Catalogus nummer: (ENZOBMLEI2280010)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: AG-494 is a member of the tyrphostin family of tyrosine kinase inhibitors and is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 µM) and EGF-dependent cell growth (IC50=6 µM). It selectively inhibits HER1 (EGF receptor) vs. HER1-2 receptor autophosphorylation (HER1: IC50=1.1 µM; HER1-2: IC50=45 µM). HER1-2 is a chimeric receptor consisting of the external HER1 domain fused to an internal HER2 domain. Blocks CDK2 activation and causescells to arrest at late G1 and during S phase.
UOM: 1 * 10 mg
Image Unavailable-BOSSBS-3299R-CY5

Anti-NEDD4L Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-3299R-CY5)
Leverancier: Bioss
Omschrijving: E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5883R-FITC

Anti-SLC9A3R1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalogus nummer: (BOSSBS-5883R-FITC)
Leverancier: Bioss
Omschrijving: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5883R-CY5.5

Anti-SLC9A3R1 Rabbit Polyclonal Antibody (Cy5.5®)

Catalogus nummer: (BOSSBS-5883R-CY5.5)
Leverancier: Bioss
Omschrijving: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3907R-CY3

Anti-LGMN Rabbit Polyclonal Antibody (Cy3®)

Catalogus nummer: (BOSSBS-3907R-CY3)
Leverancier: Bioss
Omschrijving: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3907R-CY5

Anti-LGMN Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-3907R-CY5)
Leverancier: Bioss
Omschrijving: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5883R-HRP

Anti-SLC9A3R1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalogus nummer: (BOSSBS-5883R-HRP)
Leverancier: Bioss
Omschrijving: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.
UOM: 1 * 100 µl
Image Unavailable-SARBMCA2.7S2S00-M

Ultra-micro laboratoriumweegschalen, Cubis® II MCA

Leverancier: Sartorius Balances
Omschrijving: Cubis® II MCA ultra-microweegschalen met geavanceerde gebruikersinterface bieden een afleesbaarheid van 0,1 µg en een maximale capaciteit van 2,1 g. Wordt gebruikt om het exacte gewicht van de kleinste monsterhoeveelheden te bepalen.

Product Image-SARBMCE10.6S2S00-M

Micro laboratoriumbalansen, Cubis® II MCE

Leverancier: Sartorius Balances
Omschrijving: Cubis® II MCE microbalansen met essentiële gebruikersinterface bieden een afleesbaarheid van 1 μg en een maximale capaciteit tussen 3,1 en 10,1 g. Wordt gebruikt om het exacte gewicht van zeer kleine monsterhoeveelheden te bepalen.

Product Image-BELL37-62

Digital polarimeters, ADP600

Leverancier: BELLINGHAM STANLEY
Omschrijving: The ADP600 high precision polarimeters with internal Peltier temperature control are capable of measuring optical rotation to four decimal places angular across the UV/Visible spectrum using standard glass or low volume leur taper flow-through tubes.

Image Unavailable-BOSSBS-0676R-A555

Anti-FGFR4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalogus nummer: (BOSSBS-0676R-A555)
Leverancier: Bioss
Omschrijving: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
UOM: 1 * 100 µl
Bel voor prijs
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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