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Image Unavailable-SHBTPB-500-14

Mouse Recombinant Mouse Th17 Cell Polarizing Plus PB (from E. coli)

Catalogus nummer: (SHBTPB-500-14)
Leverancier: Shenandoah Biotechnology
Omschrijving: Cytokines for polarising mouse T cells into Th17 cells. T helper 17 cells (Th17) are a distinct type of T cell subset that are thought to be important in immunity against microbes at the epitilial and mucosal interfaces of the body. Disruption of the regular function or balance of Th17 cells is thought to be involved in several autoimmune diseases and/or opportunistic infections. Th17 cells are characterised by their ability to produce IL-17, IL-22 and IL-21. Th17 cells can be cultured from naive CD4+ T cells by culturing them in the presence of anti-CD3 and anti-CD28 stimulation with recombinant IL-6 and recombinant TGF-β 1. In some cases neutralising antibodies against IL-12, IL-4 and IFNγ are used along with recombinat cytokines IL-1 β, IL-21 and/or IL-23.
UOM: 1 * 1 Kit

New Product


Product Image-113-8637

Cleanroom frocks, Tyvek® IsoClean® model IC270B MS

Leverancier: DuPont
Omschrijving: These frocks deliver an ideal balance of protection, durability and comfort. Made using a patented flash spinning process, Tyvek® provides an inherent barrier to particles, microorganisms and non hazardous light liquid splash.

Image Unavailable-BOSSBS-12274R-HRP

Anti-OVOL2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalogus nummer: (BOSSBS-12274R-HRP)
Leverancier: Bioss
Omschrijving: The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental signaling pathways such as Wnt and TGF-∫/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12025R

Anti-GPR116 Rabbit Polyclonal Antibody

Catalogus nummer: (BOSSBS-12025R)
Leverancier: Bioss
Omschrijving: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR116 (G protein-coupled receptor 116) is a 1,346 amino acid multi-pass membrane protein that contains one SEA domain, one GPS domain and three Ig-like domains and belongs to the GPR family. Existing as a dilsulfide-liked homodimer at the cell surface, GPR116 exists as multiple alternatively spliced isoforms and is thought to play a role in regulating and maintaining proper acid-base balance throughout the cell.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2988R-CY7

Anti-MFN2 Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-2988R-CY7)
Leverancier: Bioss
Omschrijving: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
UOM: 1 * 100 µl
Product Image-611-5068

Cent-O-Gram® en Dial-O-Gram®

Leverancier: OHAUS
Omschrijving: Afneembare roestvrijstalen pan, aluminium drukgegoten basis en balk. Deze balansen bieden een hoge precisie en uitstekende waarde en zijn wereldwijd populair in het onderwijs en de industrie.

Product Image-611-2407

Precisiebalansen, Explorer®

Leverancier: OHAUS
Omschrijving: Een reeks balansen met een touchscreen, geavanceerde weeg- en nabijheidssensortechnologieën. De gebruiksvriendelijke bedieningseenheid kan worden gemonteerd op een basis, boven een basis op een optionele kolom, aan een muur of op afstand (tot 3 meter afstand met een optionele kabel). Het touchscreen-display, met universele pictogrammen en informatieve prompts, vereenvoudigt de instelfuncties en basisbediening. Vervolgens heeft de operator de extra keuze om nabijheidssensoren te gebruiken voor handsfree bediening bij het hanteren van gevoelige monsters. Deze balansen hebben meerdere toepassingsmodi van basiswegen tot SQC-toepassingen, samen met korte stabilisatietijden en geoptimaliseerde prestatiespecificaties.

Product Image-AATB20011

HHBS [Hanks' Buffer with 20 mM HEPES] (100 ml)

Catalogus nummer: (AATB20011)
Leverancier: AAT BIOQUEST
Omschrijving: Hank's Balanced Salt Solution with 20 mM Hepes buffer (HHBS) is used for a variety of cell culture applications, such as washing cells, transporting cells or tissue samples, diluting cells for counting, and preparing reagents.
UOM: 1 * 100 mL
Image Unavailable-BOSSBS-2912R-A647

Anti-MAP1A/MAP1B LC3 A/B Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-2912R-A647)
Leverancier: Bioss
Omschrijving: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2912R-A555

Anti-MAP1A/MAP1B LC3 A/B Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalogus nummer: (BOSSBS-2912R-A555)
Leverancier: Bioss
Omschrijving: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
UOM: 1 * 100 µl
Image Unavailable-OHAU30820352

COURIER™ 1000 compacte draagbare verzendweegschalen

Leverancier: OHAUS
Omschrijving: Courier 1000-serie verzendweegschalen, een veelzijdige lijn van lichtgewicht, duurzame weegapparatuur die alles aankan, van algemene verzendtoepassingen voor bedrijven tot lichte weegtaken voor dierenartspraktijken.

Image Unavailable-BOSSBS-8487R-CY5

Anti-FNDC3B Rabbit Polyclonal Antibody (Cy5®)

Catalogus nummer: (BOSSBS-8487R-CY5)
Leverancier: Bioss
Omschrijving: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8487R-CY5.5

Anti-FNDC3B Rabbit Polyclonal Antibody (Cy5.5®)

Catalogus nummer: (BOSSBS-8487R-CY5.5)
Leverancier: Bioss
Omschrijving: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12938R-CY7

Anti-CSGALNACT1 Rabbit Polyclonal Antibody (Cy7®)

Catalogus nummer: (BOSSBS-12938R-CY7)
Leverancier: Bioss
Omschrijving: The chondroitin N-acetylgalactosaminyltransferase family includes Beta-1,4-GalNAc-T, Beta-1,4-GalNAc-T2, Beta-1,4-GalNAc-T3 and Beta-1,4-GalNAc-T4. The Beta-1,4-GalNAc-T protein consists of a short N-terminal residue, a transmembrane region and a long C-terminal residue, which includes a catalytic domain and localizes to the Golgi apparatus. Beta-1,4-GalNAc-T utilizes simple ganglioside GM3 as a substrate for more complex gangliosides GM2, GM1 and GD1a. Beta-1,4-GalNAc-T is expressed in normal brain tissues and in various malignant transformed cells, such as malignant melanoma, neuroblastoma and adult T cell leukemia. Mice lacking the Beta-1,4-GalNAc-T protein develop significant and progressive behavioral neuropathies, including deficits in reflexes, strength, coordination and balance. Beta-1,4-GalNAc-T is a potential molecular marker for detecting melanoma cells and monitoring tumor progression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12938R-A555

Anti-CSGALNACT1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalogus nummer: (BOSSBS-12938R-A555)
Leverancier: Bioss
Omschrijving: The chondroitin N-acetylgalactosaminyltransferase family includes Beta-1,4-GalNAc-T, Beta-1,4-GalNAc-T2, Beta-1,4-GalNAc-T3 and Beta-1,4-GalNAc-T4. The Beta-1,4-GalNAc-T protein consists of a short N-terminal residue, a transmembrane region and a long C-terminal residue, which includes a catalytic domain and localizes to the Golgi apparatus. Beta-1,4-GalNAc-T utilizes simple ganglioside GM3 as a substrate for more complex gangliosides GM2, GM1 and GD1a. Beta-1,4-GalNAc-T is expressed in normal brain tissues and in various malignant transformed cells, such as malignant melanoma, neuroblastoma and adult T cell leukemia. Mice lacking the Beta-1,4-GalNAc-T protein develop significant and progressive behavioral neuropathies, including deficits in reflexes, strength, coordination and balance. Beta-1,4-GalNAc-T is a potential molecular marker for detecting melanoma cells and monitoring tumor progression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12938R-A647

Anti-CSGALNACT1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalogus nummer: (BOSSBS-12938R-A647)
Leverancier: Bioss
Omschrijving: The chondroitin N-acetylgalactosaminyltransferase family includes Beta-1,4-GalNAc-T, Beta-1,4-GalNAc-T2, Beta-1,4-GalNAc-T3 and Beta-1,4-GalNAc-T4. The Beta-1,4-GalNAc-T protein consists of a short N-terminal residue, a transmembrane region and a long C-terminal residue, which includes a catalytic domain and localizes to the Golgi apparatus. Beta-1,4-GalNAc-T utilizes simple ganglioside GM3 as a substrate for more complex gangliosides GM2, GM1 and GD1a. Beta-1,4-GalNAc-T is expressed in normal brain tissues and in various malignant transformed cells, such as malignant melanoma, neuroblastoma and adult T cell leukemia. Mice lacking the Beta-1,4-GalNAc-T protein develop significant and progressive behavioral neuropathies, including deficits in reflexes, strength, coordination and balance. Beta-1,4-GalNAc-T is a potential molecular marker for detecting melanoma cells and monitoring tumor progression.
UOM: 1 * 100 µl
Bel voor prijs
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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