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TriLink® CleanCap® Cre mRNA (5 moU)

Leverancier: TriLink BioTechnologies

Omschrijving: NLS-Cre Recombinase mRNA is a capped and polyadenylated messenger RNA encoding Cre recombinase fused to a nuclear localisation sequence (NLS). Cre recombinase is a tyrosine recombinase that catalyzes recombination between two loxP sites.

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TriLink® CleanCap® Cas9 Nickase mRNA (5 moU)

Leverancier: TriLink BioTechnologies

Omschrijving: Cas9 Nickase mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9) that contains a D10A amino acid substitution. This mRNA also contains a C-terminal nuclear localisation signal followed by a HA tag.

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TriLink® N1-Methyl-Pseudouridine-5'-Triphosphate

Leverancier: TriLink BioTechnologies

Omschrijving: N1-Methyl-Pseudouridine-5'-Triphosphate is widely used in mRNA synthesis for therapeutic and vaccine development to improve mRNA functionality. This nucleotide consists of a modified base, a ribose, and a 5′ triphosphate group.

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TriLink® CleanCap® FLuc mRNA (5 moU)

Leverancier: TriLink BioTechnologies

Omschrijving: The FLuc mRNA expresses a luciferase protein, originally isolated from the firefly, Photinus pyralis. FLuc is commonly used in mammalian cell culture to measure both gene expression and cell viability. It emits bioluminescence in the presence of the substrate, luciferin.

TriLink® CleanCap® Cas9 mRNA (5 moU)

Leverancier: TriLink BioTechnologies

Omschrijving: Cas9 mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9). Cas9 functions as part of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest, and the Cas9 protein is employed to perform double-stranded DNA cleavage.

TriLink® CleanCap® Cas9 mRNA

Leverancier: TriLink BioTechnologies

Omschrijving: Cas9 mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9). Cas9 functions as part of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest and the Cas9 protein is employed to perform double stranded DNA cleavage.

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TriLink® 7-Deaza-2'-deoxyguanosine-5'-Triphosphate

Leverancier: TriLink BioTechnologies

Omschrijving: This deoxyguanosine analog lacks the N7 nitrogen found in the natural guanine nucleobase. Replacement of this nitrogen atom with a carbon atom results in diminished structure of the major groove in DNA and may disrupt base stacking, but does not interfere with Watson-Crick base pairing. This is desirable for applications such as amplification and sequencing of GC-rich nucleic acid sequences.

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TriLink® N6-Methyladenosine-5'-Triphosphate

Leverancier: TriLink BioTechnologies

Omschrijving: N6-methyl adenosine (N6-methyl ATP) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs (Meyer et al.). N6-methyl ATP can substitute for ATP in some biological systems, and is a potent agonist for P2Y-purinoceptors in the guinea pig, taenia coli (Burnstock et al.).

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TriLink® CleanCap® M6 Cas9 mRNA (N1MePsU)

Leverancier: TriLink BioTechnologies

Omschrijving: Cas9 mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9). Cas9 functions as part of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest and the Cas9 protein is employed to perform double-stranded DNA cleavage.

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TriLink® CleanCap® FLuc mRNA

Leverancier: TriLink BioTechnologies

TriLink® CleanCap® EPO mRNA (5moU)

Leverancier: TriLink BioTechnologies

Omschrijving: EPO mRNA encodes the human erythropoietin (EPO) protein, a hormone that controls erythropoiesis, or red blood cell production. EPO also plays a role in wound healing and the brain’s response to neural injury. Kariko et al. showed that transfection of EPO mRNA in vivo resulted in significant increases of both reticulocyte counts and hematocrits.

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TriLink® CleanCap® M6 EPO mRNA (N1MePsU)

Leverancier: TriLink BioTechnologies

Omschrijving: EPO mRNA encodes the human erythropoietin (EPO) protein, a hormone that controls erythropoiesis, or red blood cell production. EPO also plays a role in wound healing and the brain’s response to neural injury. Kariko et al. showed that transfection of EPO mRNA in vivo resulted in significant increases of both reticulocyte counts and hematocrits.

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