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Image Unavailable-APOSOR10921-100G

Dibenzo-18-crown-6-(dibenzo-1,4,7,10,13,16-hexaoxacyclooctadecane, tin(II) ionophore I)

Catalogus nummer: (APOSOR10921-100G)
Leverancier: Apollo Scientific
Omschrijving: Dibenzo-18-crown-6-(dibenzo-1,4,7,10,13,16-hexaoxacyclooctadecane, tin(II) ionophore I)
UOM: 1 * 100 g
Product Image-ACRO169800100

Dibenzo-18-crown-6-(dibenzo-1,4,7,10,13,16-hexaoxacyclooctadecane, tin(II) ionophore I) 98+%

Leverancier: Thermo Fisher Scientific
Omschrijving: Dibenzo-18-crown-6-(dibenzo-1,4,7,10,13,16-hexaoxacyclooctadecane, tin(II) ionophore I) 98+%

MSDS

Image Unavailable-8.01268.0250

2-Aminobenzothiazole, Sigma-Aldrich®

Leverancier: Merck
Omschrijving: 2-Aminobenzothiazole, Sigma-Aldrich®

MSDS

Image Unavailable-TCIAD1533-5G

Dibenzo-18-crown-6-(dibenzo-1,4,7,10,13,16-hexaoxacyclooctadecane, tin(II) ionophore I) ≥99.0% (by GC)

Leverancier: TCI
Omschrijving: Dibenzo-18-crown-6-(dibenzo-1,4,7,10,13,16-hexaoxacyclooctadecane, tin(II) ionophore I) ≥99.0% (by GC)

Image Unavailable-59001.

Calcimycin (A23187) free acid ≥98% (by TLC) ionophore

Catalogus nummer: (59001.)
Leverancier: Biotium
Omschrijving: A-23187, also known as Calcimycin or Calcium Ionophore III, is a calcium ionophore that rapidly equilibrates intracellular and extracellular calcium concentrations. It is commonly used for in situ calibrations of fluorescent calcium indicators. The ionophore allows Mn2 to enter the cells and quench intracellular fluorescence of calcium indicators.
UOM: 1 * 1 mg
Image Unavailable-APOSBIB1001-5MG

4-Bromo-A-23187

Leverancier: Apollo Scientific
Omschrijving: Calcium ionophore, analog of calcium ionophore A23187.

Image Unavailable-72015-50MG

Sodium tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate trihydrate, Selectophore™ ionophore, Supelco®

Catalogus nummer: (72015-50MG)
Leverancier: Merck
Omschrijving: Lipophilic ion exchanger for ion-selective membrane electrodes.
UOM: 1 * 50 mg
Image Unavailable-APOSBIC1006-10MG

Calcimycin (A23187)

Leverancier: Apollo Scientific
Omschrijving: Calcium ionophore.

Image Unavailable-BOSSBS-0076R-A680

Anti-beta Amyloid 1-42 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalogus nummer: (BOSSBS-0076R-A680)
Leverancier: Bioss
Omschrijving: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalisation of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalysed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses.
UOM: 1 * 100 µl
Product Image-59007.

Ionomycin calcium salt ionophore

Catalogus nummer: (59007.)
Leverancier: Biotium
Omschrijving: Ionomycin is commonly used to modify intracellular calcium concentrations and to calibrate fluorescent calcium indicators. It is also known for its antiproliferative effects.
UOM: 1 * 1 mg
Image Unavailable-ENZOBMLKC1400025

Valinomycin ≥97% (by TLC), white solid

Catalogus nummer: (ENZOBMLKC1400025)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Potassium ionophore.
UOM: 1 * 25 mg
Product Image-ACRO328080010

Calcimycin (A23187) free acid 98%

Leverancier: Thermo Fisher Scientific
Omschrijving: CAS No.: 52665-69-7

MSDS

Image Unavailable-ENZOALX380238M001

Trinactin ≥95% (by HPLC), colourless film

Catalogus nummer: (ENZOALX380238M001)
Leverancier: ENZO LIFE SCIENCES
Omschrijving: Cation ionophore.
UOM: 1 * 1 mg
Image Unavailable-ENZOADISPA224D

Anti-CRYAA Rabbit Polyclonal Antibody

Leverancier: ENZO LIFE SCIENCES
Omschrijving: Alpha-crystallins composed of alpha A (~20 kDa) and alpha B (~20 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. The two other crystallin families, beta and gamma, are homologous to each other but not to the alpha family or the sHsp's. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The alpha-crystallins have sequence homology as well as structural and functional similarities with the small Hsp's such as Hsp25/27. Most small heat shock proteins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of alphaA-crystallin, alphaB-crystallin and Hsp25/27; (iii) the moderately conserved alpha-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The alpha-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation, although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease.

Image Unavailable-APOSBII0123-10MG

Ionomycin calcium salt

Leverancier: Apollo Scientific
Omschrijving: Potent and selective calcium ionophore.

Image Unavailable-APOSBII0421-10MG

Ionomycin free acid

Leverancier: Apollo Scientific
Omschrijving: Potent and selective calcium ionophore.

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