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Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG2a antibody against mouse NK1.1 (CD161), APC-conjugated.

Catalogus nummer: (STMC19665)

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic isolation of NK cells directly from whole blood

UOM: 1 * 1 Kit

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Leverancier: STEMCELL Technologies

Omschrijving: Insulin-like growth factor 1 (IGF-I) is a polypeptide which belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway; it also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with interleukin 3 (IL-3), IGF-I stimulates differentiation and proliferation of myeloid cells, and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG1 antibody against human, rhesus, chimpanzee CD73, APC-conjugated.

Leverancier: STEMCELL Technologies

Omschrijving: Immunodensity depletion of granulocytes for HLA analysis.

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), APC-conjugated.

Catalogus nummer: (STMC19061RF)

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic isolation of untouched human myeloid dendritic cells (mDCs).

UOM: 1 * 1 Kit

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Catalogus nummer: (STMC60120PE)

Leverancier: STEMCELL Technologies

Omschrijving: Mouse monoclonal IgG1, kappa isotype control antibody, PE-conjugated.

UOM: 1 * 1 EA

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Leverancier: STEMCELL Technologies

Omschrijving: Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran <i>et al.</i>). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani <i>et al.</i>). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing <i>et al.</i>; Deshmane <i>et al.</i>). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Fibroblast growth factor 4 (FGF-4) is a member of the FGF superfamily (Beenken and Mohammadi). FGF-4 is expressed in pluripotent stem cells and is implicated in various stages of development and morphogenesis in a variety of organisms (Kosaka <i>et al.</i> 2009). FGF-4 has been shown to have an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain (Kosaka <i>et al.</i> 2006). FGF-4 has also been shown to increase the proliferation rate of mesenchymal stem cells (Farré <i>et al.</i>). FGF-4 supports the maintenance and self-renewal properties of human embryonic stem cells and also promotes the proliferation of these cells (Mayshar <i>et al.</i>). In the mouse, the Fgf4 gene also supports proliferation of the inner cell mass (ICM) and postimplantation embryos (Feldman <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto <i>et al.</i>; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim <i>et al.</i>). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto <i>et al.</i>; Sachinidis <i>et al.</i>). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan <i>et al.</i>).

Leverancier: STEMCELL Technologies

Omschrijving: Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara <i>et al.</i>). It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>).

Catalogus nummer: (STMC100-0825)

Leverancier: STEMCELL Technologies

Omschrijving: Culture medium kit for maturation of human pluripotent stem cell-derived choroid plexus organoids.

UOM: 1 * 1 Kit

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Catalogus nummer: (STMC07060)

Leverancier: STEMCELL Technologies

Omschrijving: 3% Acetic Acid with Methylene Blue. Reagent for manual counting of nucleated mammalian cells

UOM: 1 * 100 mL

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Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic isolation of untouched mouse memory CD4 T cells

Leverancier: STEMCELL Technologies

Omschrijving: Immunomagnetic isolation of untouched human cells